MolNFT v1 · #163144 · protein
Light-regulation of imidazole glycerol phosphate synthase by interference with its allosteric machinery through photo-sensitive unnatural amino acids
6RTZ · Imidazole glycerol phosphate synthase subunit hisf: “Light-regulation of imidazole glycerol phosphate synthase by interference with its allosteric machinery…”. X-ray diffraction, 1 ligand (PO4), 4 pockets (best druggability 0.70).…
- PDB
- 6RTZ
- Type
- protein
- Length
- 452 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Imidazole glycerol phosphate synthase subunit hisf; Imidazole glycerol phosphate synthase…
- EC
- 4.3.2.10, 3.5.1.2
- UniProt
- Q9X0C6, Q9X0C8
- Ligands
- PO4
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Imidazole glycerol phosphate synthase subunit hisf (EC 4.3.2.10) | protein | 252 | 37% helix, 27% strand | Q9X0C6 |
| B | Imidazole glycerol phosphate synthase subunit hish (EC 4.3.2.10, 3.5.1.2) | protein | 200 | 27% helix, 36% strand | Q9X0C8 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 608 | 0.70 | 0.78 | 52 | PO4 |
| 2 | 328 | 0.70 | 0.83 | 42 | empty |
| 3 | 136 | 0.51 | 0.80 | 19 | empty |
| 4 | 57 | 0.33 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1132 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6RTZ · Light-Regulation of Imidazole Glycerol Phosphate Synthase by Interference with its… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9X0C8 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hish… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9X0C6 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hisf… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0C6
- Every structure of UniProt Q9X0C8
- Elsewhere: RCSB PDB 6RTZ · PDBe 6RTZ · UniProt Q9X0C6 · UniProt Q9X0C8
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