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Crystal structure of EIF4A-I in complex with RNA bound to des-mepatea, a pateamine a analog

Analyse Crystal structure of EIF4A-I in complex with RNA bound to des-mepatea, a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XKI
Type: protein + RNA
Length: 388 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P60843
Ligands: ANP, V6D, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	378	—	P60843
B	—	rna	10	—	—

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
V6D · (3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9, 11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione · ligand · chains A, B
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6XKI · Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A… · the same entry in another collection · chain A against A, TM-score 1.00
P60843 · AlphaFold monomer V2.0 prediction for eukaryotic initiation factor 4A-I (P60843) · a predicted model of the same protein · chain A against A, TM-score 0.97

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Every structure of UniProt P60843
Elsewhere: RCSB PDB 6XKI · PDBe 6XKI · UniProt P60843

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