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Crystal structure of KRAS-Q61R (gmppnp-bound) in complex with RAS- binding domain (rbd) and cysteine-rich domain (crd) of RAF1/CRAF

Analyse Crystal structure of KRAS-Q61R (gmppnp-bound) in complex with RAS- binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XGU
Type: protein
Length: 302 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P01116, P04049
Ligands: GNP, ZN, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	168	—	P01116
B	—	protein	134	—	P04049

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
ZN · Zinc ion · metal · 3 copies · chains A, B
MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6XGU · Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD)… · the same entry in another collection · chain A against A, TM-score 1.00
P04049 · AlphaFold monomer V2.0 prediction for RAF proto-oncogene SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01116
Every structure of UniProt P04049
Elsewhere: RCSB PDB 6XGU · PDBe 6XGU · UniProt P01116 · UniProt P04049

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