Crystal structure of human H-chain ferritin variant 157C delta C-star modified with a raft agent soaked in an acrylate solution

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Ligands and binding sites

• RFT · butyl 1-{[2-(2,5-dioxopyrrolidin-1-yl)ethyl]amino}-2-methyl-1-oxopropan-2-yl carbonotrithioate · ligand · chains A
• CA · Calcium ion · metal · 11 copies · chains A
• FE · Fe (III) ion · metal · 2 copies · chains A
• NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 6WYF · Crystal structure of Human H-chain Ferritin variant 157C Delta C-star Modified with a… · the same entry in another collection · chain A against A, TM-score 1.00
• P02794 · AlphaFold monomer V2.0 prediction for ferritin heavy chain (P02794) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P02794
• Elsewhere: RCSB PDB 6WYF · PDBe 6WYF · UniProt P02794