UniProt P02794
Ferritin heavy chain (P02794)
Ferritin heavy chain (UniProt P02794), EC 1.16.3.1: 192 experimental structures and 1 predicted model on GenesisL1, 23 ligands bound, 992 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02794
- Protein
- Ferritin heavy chain
- EC
- 1.16.3.1
- Experimental structures
- 192
- Predicted models
- 1
- Ligands
- 23
- Pockets
- 992 · 54 records with a druggable one
Structures
193 records of P02794 in the MolNFT archive: 192 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FHA | Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts | x-ray diffraction | A | — | — |
| 1FHA | Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts | x-ray diffraction | A | — | — |
| 2CEI | Recombinant human H ferritin, K86Q mutant, soaked with Zn | x-ray diffraction | A | — | — |
| 2CEI | Recombinant human H ferritin, K86Q mutant, soaked with zn | x-ray diffraction | A | — | — |
| 2CHI | Recombinant human H ferritin, K86Q and E27D mutant | x-ray diffraction | A | — | — |
| 2CHI | Recombinant human H ferritin, K86Q and E27D mutant | x-ray diffraction | A | — | — |
| 2CIH | Recombinant human H ferritin, K86Q and E27D mutant, soaked with Zn | x-ray diffraction | A | — | — |
| 2CIH | Recombinant human H ferritin, K86Q and E27D mutant, soaked with zn | x-ray diffraction | A | — | — |
| 2CLU | Recombinant human H ferritin, K86Q and E107D mutant | x-ray diffraction | A | — | — |
| 2CLU | Recombinant human H ferritin, K86Q and E107D mutant | x-ray diffraction | A | — | — |
| 2CN6 | Recombinant human H ferritin, K86Q and E107D mutant, soaked with Zn ions | x-ray diffraction | A | — | — |
| 2CN6 | Recombinant human H ferritin, K86Q and E107D mutant, soaked with zn ions | x-ray diffraction | A | — | — |
| 2CN7 | Recombinant human H ferritin, K86Q, E27D and E107D mutant | x-ray diffraction | A | — | — |
| 2CN7 | Recombinant human H ferritin, K86Q, E27D and E107D mutant | x-ray diffraction | A | — | — |
| 2FHA | Human H chain ferritin | x-ray diffraction | A | — | — |
| 2FHA | Human H chain ferritin | x-ray diffraction | A | — | — |
| 2IU2 | Recombinant human H ferritin, K86Q, E27D and E107D mutant, soaked with Zn ions | x-ray diffraction | A | — | — |
| 2IU2 | Recombinant human H ferritin, K86Q, E27D and E107D mutant, soaked with zn ions | x-ray diffraction | A | — | — |
| 2Z6M | Crystal structure of Human Ferritin H8 as biotemplate for noble metal nanoparticle synthesis | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2Z6M | Crystal structure of human ferritin H8 as biotemplate for noble metal nanoparticle synthesis | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3AJO | Crystal structure of wild-type human ferritin H chain | x-ray diffraction | A | — | — |
| 3AJO | Crystal structure of wild-type human ferritin H chain | x-ray diffraction | A | — | — |
| 3AJP | Crystal structure of human H ferritin E140A mutant | x-ray diffraction | A | — | — |
| 3AJP | Crystal structure of human H ferritin E140A mutant | x-ray diffraction | A | — | — |
| 3AJQ | Crystal structure of human H ferritin E140Q mutant | x-ray diffraction | A | — | — |
| 3AJQ | Crystal structure of human H ferritin E140Q mutant | x-ray diffraction | A | — | — |
| 3ERZ | Directing Noble Metal Ion Chemistry within a Designed Ferritin Protein. Mercury Ions on the… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3ERZ | Directing noble metal ion chemistry within a designed ferritin protein. mercury ions on the… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 3ES3 | Directing Noble Metal Ion Chemistry within a Designed Ferritin Protein. The Complex with Gold ions.… | x-ray diffraction | A | — | — |
| 3ES3 | Directing noble metal ion chemistry within a designed ferritin protein. the complex with gold ions.… | x-ray diffraction | A | — | — |
| 4DYX | Crystal Structure of the Cu-adduct of Human H-Ferritin variant 4His-delta C-star | x-ray diffraction | A | — | — |
| 4DYX | Crystal structure of the cu-adduct of human H-ferritin variant 4HIS- delta C-star | x-ray diffraction | A | — | — |
| 4DYY | Crystal Structure of the Cu-adduct of Human H-Ferritin variant MIC1 | x-ray diffraction | A | — | — |
| 4DYY | Crystal structure of the cu-adduct of human H-ferritin variant MIC1 | x-ray diffraction | A | — | — |
| 4DYZ | Crystal Structure of the apo form of Human H-Ferritin variant MIC1 | x-ray diffraction | A | — | — |
| 4DYZ | Crystal structure of the apo form of human H-ferritin variant MIC1 | x-ray diffraction | A | — | — |
| 4DZ0 | Crystal structure of the Cu-adduct of human H-Ferritin variant MIC1 labeled with a dansyl… | x-ray diffraction | A | — | — |
| 4DZ0 | Crystal structure of the cu-adduct of human H-ferritin variant MIC1 labeled with a dansyl… | x-ray diffraction | A | — | — |
| 4OYN | Fifteen minutes iron loaded human H ferritin | x-ray diffraction | A | — | — |
| 4OYN | Fifteen minutes iron loaded human H ferritin | x-ray diffraction | A | — | — |
| 4Y08 | One minute iron loaded human H ferritin | x-ray diffraction | A | FE2, CL, MG, OXY | — |
| 4Y08 | One minute iron loaded human H ferritin | x-ray diffraction | A | — | — |
| 4YKH | Thirty minutes iron loaded human H ferritin | x-ray diffraction | A | — | — |
| 4YKH | Thirty minutes iron loaded human H ferritin | x-ray diffraction | A | — | — |
| 4ZJK | Five minutes iron loaded human H ferritin | x-ray diffraction | A | FE2, MG, CL | 1 (best 0.28) |
| 4ZJK | Five minutes iron loaded human H ferritin | x-ray diffraction | A | — | — |
| 5CMQ | Crystal Structure of Zn-bound Human H-Ferritin variant 122H-delta C-star | x-ray diffraction | A | ZN | — |
| 5CMQ | Crystal structure of zn-bound human H-ferritin variant 122H-delta C- star | x-ray diffraction | A | — | — |
| 5CMR | Crystal Structure of Linker-Mediated Zn-bound Human H-Ferritin variant 122H-delta C-star | x-ray diffraction | A | ZN, NA, BYD | — |
| 5CMR | Crystal structure of linker-mediated zn-bound human H-ferritin variant 122H-delta C-star | x-ray diffraction | A | — | — |
| 5GN8 | Structure of a 48-mer protein nanocage fabricated from its 24-mer analogue by subunit interface… | x-ray diffraction | A, B | CA | 3 (best 0.74) |
| 5GN8 | Structure of a 48-mer protein nanocage fabricated from its 24-mer analogue by subunit interface… | x-ray diffraction | A, B | — | — |
| 5GOU | Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface… | x-ray diffraction | A, B, C, D, F, E, H, G, J, I, L, K, N, M, P, O | — | 20 (best 0.76) |
| 5GOU | Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface… | x-ray diffraction | A, B, C, D, F, E, H, G, J, I, L, K, N, M, P, O | — | — |
| 5JKK | Crystal structure of the negatively supercharged variant Ftn(neg) of human heavy chain ferritin | x-ray diffraction | A, B, C, D, E, F, G, H | FE, MG, CL | 16 (best 0.66) |
| 5JKK | Crystal structure of the negatively supercharged variant FTN(NEG) of human heavy chain ferritin | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5JKL | Binary crystal structure of positively and negatively supercharged variants Ftn(pos) and Ftn(neg)… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | FE, MG, CL | — |
| 5JKL | Binary crystal structure of positively and negatively supercharged variants FTN(POS) and FTN(NEG)… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5JKM | Binary crystal structure of positively and negatively supercharged variants Ftn(pos) and Ftn(neg)… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | FE, MG | — |
| 5JKM | Binary crystal structure of positively and negatively supercharged variants FTN(POS) and FTN(NEG)… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
133 records more on the page itself.
Ligands
- FE · Fe (III) ion · in 47 records
- NA · Sodium ion · in 44 records
- MG · Magnesium ion · in 43 records
- CL · Chloride ion · in 32 records
- CA · Calcium ion · in 25 records
- ZN · Zinc ion · in 18 records
- NI · Nickel (II) ion · in 11 records
- V9Y · N~2~,N~5~-dihydroxyfuran-2,5-dicarboxamide · in 7 records
- FE2 · Fe (II) ion · in 6 records
- RFT · butyl 1-{[2-(2,5-dioxopyrrolidin-1-yl)ethyl]amino}-2-methyl-1-oxopropan-2-yl carbonotrithioate · in 6 records
- OXY · Oxygen molecule · in 5 records
- BYD · N,N'-dihydroxybenzene-1,4-dicarboxamide · in 3 records
- 73M · bis(azanyl)-chloranyl-oxidanyl-platinum · in 2 records
- BYX · 2,2'-(1,4-phenylene)bis(N-hydroxyacetamide) · in 2 records
- CO · Cobalt (II) ion · in 2 records
- CPT · Cisplatin · in 2 records
- CU · Copper (II) ion · in 2 records
- RU · Ruthenium ion · in 2 records
- V9D · N~1~,N~3~-dihydroxybenzene-1,3-dicarboxamide · in 2 records
- AU · Gold ion · in 1 record
- NO · Nitric oxide · in 1 record
- O3K · 2-bromanyl-N-decyl-ethanamide · in 1 record
- PT · Platinum (II) ion · in 1 record
Experiment against prediction
- 8PP4 chain D against the predicted model P02794: TM-score 1.00, RMSD 0.23 Å
- 8PP3 chain E against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain A against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain B against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain C against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain D against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain E against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain F against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain G against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
- 7K3V chain H against the predicted model P02794: TM-score 1.00, RMSD 0.24 Å
Elsewhere
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