Research workbench
Clpp and clpx igf loop in clpx-clpp complex bound to ssra tagged GFP
Analyse Clpp and clpx igf loop in clpx-clpp complex bound to ssra tagged GFP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WR2
- Type
- protein
- Length
- 2,729 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent clp protease ATP-binding subunit clpx; ATP-dependent clp protease…
- EC
- 3.4.21.92
- UniProt
- P0A6H1, P0A6G7
- Pockets
- 20 · best druggability 0.74
Structure
electron microscopy · 7 distinct chains · 45% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | ATP-dependent clp protease ATP-binding subunit clpx | protein | 9 | 0% helix, 0% strand | P0A6H1 |
| h, j | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 188 | 46% helix, 26% strand | P0A6G7 |
| i, k, l | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 190 | 45% helix, 26% strand | P0A6G7 |
| m | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 189 | 46% helix, 24% strand | P0A6G7 |
| n | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 191 | 47% helix, 24% strand | P0A6G7 |
| M, H, I, J, K, L | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 192 | 44% helix, 26% strand | P0A6G7 |
| N | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 197 | 45% helix, 25% strand | P0A6G7 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 882 | 0.74 | 0.78 | 110 | empty |
| 2 | 563 | 0.74 | 0.81 | 79 | empty |
| 3 | 525 | 0.74 | 0.82 | 62 | empty |
| 4 | 552 | 0.74 | 0.81 | 75 | empty |
| 5 | 536 | 0.73 | 0.81 | 71 | empty |
Interfaces
48 interfaces between chains.
- M–N · 1815 Ų buried · 21 hydrogen bonds · protein-protein
- h–i · 1786 Ų buried · 23 hydrogen bonds · protein-protein
- k–l · 1781 Ų buried · 20 hydrogen bonds · protein-protein
- i–j · 1778 Ų buried · 19 hydrogen bonds · protein-protein
- j–k · 1768 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 6WR2 · ClpP and ClpX IGF loop in ClpX-ClpP complex bound to ssrA tagged GFP · the same entry in another collection · chain l against l, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6H1
- Every structure of UniProt P0A6G7
- Elsewhere: RCSB PDB 6WR2 · PDBe 6WR2 · UniProt P0A6H1 · UniProt P0A6G7
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