UniProt P0A6H1
ATP-dependent Clp protease ATP-binding subunit clpX (P0A6H1)
ATP-dependent Clp protease ATP-binding subunit clpX (UniProt P0A6H1): 36 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 98 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0A6H1
- Protein
- ATP-dependent Clp protease ATP-binding subunit clpX
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 98 · 7 records with a druggable one
Structures
37 records of P0A6H1 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OVX | NMR structure of the E. coli ClpX chaperone zinc binding domain dimer | solution nmr | A, B | ZN | — |
| 1OVX | NMR structure of the E. COLI clpx chaperone zinc binding domain dimer | solution nmr | A, B | — | — |
| 2DS5 | Structure of the ZBD in the orthorhomibic crystal from | x-ray diffraction | A, B | ZN, CA | — |
| 2DS5 | Structure of the zbd in the orthorhomibic crystal from | x-ray diffraction | A, B | — | — |
| 2DS6 | Structure of the ZBD in the tetragonal crystal form | x-ray diffraction | A, B | ZN | — |
| 2DS6 | Structure of the zbd in the tetragonal crystal form | x-ray diffraction | A, B | — | — |
| 2DS7 | Structure of the ZBD in the hexagonal crystal form | x-ray diffraction | A | ZN | — |
| 2DS7 | Structure of the zbd in the hexagonal crystal form | x-ray diffraction | A | — | — |
| 2DS8 | Structure of the ZBD-XB complex | x-ray diffraction | A, B | ZN | — |
| 2DS8 | Structure of the zbd-xb complex | x-ray diffraction | A, B | — | — |
| 3HTE | Crystal structure of nucleotide-free hexameric ClpX | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HTE | Crystal structure of nucleotide-free hexameric clpx | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HWS | Crystal structure of nucleotide-bound hexameric ClpX | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HWS | Crystal structure of nucleotide-bound hexameric clpx | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I34 | Crystal Structure of W-W-W ClpX Hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I34 | Crystal structure of W-W-W clpx hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I4L | Crystal Structure of Nucleotide-Bound W-W-W ClpX Hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I4L | Crystal structure of nucleotide-bound W-W-W clpx hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I5O | Crystal structure of W-W-R clpx hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I63 | Crystal Structure of E-R ClpX Hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I63 | Crystal structure of E-R clpx hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I81 | Crystal Structure of ATPgS bound ClpX Hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I81 | Crystal structure of atpgs bound clpx hexamer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4I9K | Crystal structure of symmetric W-W-W ClpX Hexamer | x-ray diffraction | A, B | — | — |
| 4I9K | Crystal structure of symmetric W-W-W clpx hexamer | x-ray diffraction | A, B | — | — |
| 6WR2 | ClpP and ClpX IGF loop in ClpX-ClpP complex bound to ssrA tagged GFP | electron microscopy | A, B, C, D, E, F | — | — |
| 6WR2 | Clpp and clpx igf loop in clpx-clpp complex bound to ssra tagged GFP | electron microscopy | A, B, C, D, E, F | — | — |
| 6WRF | ClpX-ClpP complex bound to GFP-ssrA, recognition complex | electron microscopy | B, C, D, E, F, A | AGS, MG, ADP | 19 (best 0.88) |
| 6WRF | Clpx-clpp complex bound to GFP-ssra, recognition complex | electron microscopy | B, C, D, E, F, A | AGS, MG, ADP | — |
| 6WSG | ClpX-ClpP complex bound to ssrA-tagged GFP, intermediate complex | electron microscopy | A, B, C, D, E, F | AGS, MG | 16 (best 0.84) |
| 6WSG | Clpx-clpp complex bound to ssra-tagged GFP, intermediate complex | electron microscopy | A, B, C, D, E, F | AGS, MG | — |
| 8E7V | Cryo-EM structure of substrate-free DNClpX.ClpP from singly capped particles | electron microscopy | A, B, C, D, E, F | ATP, MG, ADP | 12 (best 0.84) |
| 8E8Q | Cryo-EM structure of substrate-free DNClpX.ClpP | electron microscopy | A, B, C, D, E, F | ATP, MG, ADP | 13 (best 0.86) |
| 8V9R | Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA… | electron microscopy | A, B, C, D, E, F | ATP, MG, ADP | 14 (best 0.85) |
| 9C87 | Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA… | electron microscopy | A, B, C, D, E, F | ATP, MG, ADP | 13 (best 0.86) |
| 9C88 | Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Translocating a Portion of a Branched-Degron… | electron microscopy | A, B, C, D, E, F | ATP, MG, ADP | 11 (best 0.86) |
| P0A6H1 | AlphaFold monomer V2.0 prediction for ATP-dependent clp protease ATP- binding subunit clpx (P0A6H1) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4I4L chain B against the predicted model P0A6H1: TM-score 0.97, RMSD 1.17 Å
- 4I4L chain B against the predicted model P0A6H1: TM-score 0.97, RMSD 1.17 Å
- 4I34 chain B against the predicted model P0A6H1: TM-score 0.97, RMSD 1.26 Å
- 4I34 chain B against the predicted model P0A6H1: TM-score 0.97, RMSD 1.26 Å
- 4I81 chain B against the predicted model P0A6H1: TM-score 0.97, RMSD 1.18 Å
- 4I81 chain B against the predicted model P0A6H1: TM-score 0.97, RMSD 1.18 Å
- 4I34 chain E against the predicted model P0A6H1: TM-score 0.97, RMSD 1.31 Å
- 4I34 chain E against the predicted model P0A6H1: TM-score 0.97, RMSD 1.31 Å
- 4I9K chain A against the predicted model P0A6H1: TM-score 0.96, RMSD 1.28 Å
- 4I9K chain A against the predicted model P0A6H1: TM-score 0.96, RMSD 1.28 Å
Elsewhere
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