UniProt P0A6G7

ATP-dependent Clp protease proteolytic subunit (P0A6G7)

ATP-dependent Clp protease proteolytic subunit (UniProt P0A6G7), EC 3.4.21.92: 27 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 120 pockets. Binding sites, druggability and experiment against…

UniProt: P0A6G7
Protein: ATP-dependent Clp protease proteolytic subunit
EC: 3.4.21.92
Experimental structures: 27
Predicted models: 1
Ligands: 2
Pockets: 120 · 11 records with a druggable one

Structures

28 records of P0A6G7 in the MolNFT archive: 27 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1TYF	The structure of clpp at 2.3 ångström resolution suggests a model for ATP-dependent proteolysis	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	—	—
1TYF	The structure of clpp at 2.3 ångström resolution suggests a model for ATP-dependent proteolysis	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	—	—
1YG6	ClpP	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	—	—
1YG6	CLPP	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	—	—
2FZS	Crystal structure of E. coli ClpP with a Peptide Chloromethyl Ketone Covalently Bound at the Active…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	—	—
2FZS	Crystal structure of E. COLI clpp with a peptide chloromethyl ketone covalently bound at the active…	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	—	—
3HLN	Crystal structure of ClpP A153C mutant with inter-heptamer disulfide bonds	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2	—	—
3HLN	Crystal structure of clpp A153C mutant with inter-heptamer disulfide bonds	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2	—	—
3MT6	Structure of ClpP from Escherichia coli in complex with ADEP1	x-ray diffraction	R, S, T, U, O, P, Q, Y, Z, a, b, V, W, X, M, L, K, J, I, H, N, F, E, D, C, B, A, G	—	—
3MT6	Structure of clpp from escherichia COLI in complex with ADEP1	x-ray diffraction	R, S, T, U, O, P, Q, Y, Z, a, b, V, W, X, M, L, K, J, I, H, N, F, E, D, C, B, A, G	—	—
6NB1	Crystal structure of Escherichia coli ClpP protease complexed with small molecule activator, ACP1-06	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	KHS	—
6NB1	Crystal structure of escherichia COLI clpp protease complexed with small molecule activator, ACP1-06	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N	KHS	—
6WR2	ClpP and ClpX IGF loop in ClpX-ClpP complex bound to ssrA tagged GFP	electron microscopy	h, i, j, k, l, m, n, M, N, H, I, J, K, L	—	20 (best 0.74)
6WR2	Clpp and clpx igf loop in clpx-clpp complex bound to ssra tagged GFP	electron microscopy	h, i, j, k, l, m, n, M, N, H, I, J, K, L	—	—
6WRF	ClpX-ClpP complex bound to GFP-ssrA, recognition complex	electron microscopy	H, I, J, K, L, M, N	—	7 (best 0.75)
6WRF	Clpx-clpp complex bound to GFP-ssra, recognition complex	electron microscopy	H, I, J, K, L, M, N	—	—
6WSG	ClpX-ClpP complex bound to ssrA-tagged GFP, intermediate complex	electron microscopy	L, K, J, I, H, N, M	—	9 (best 0.75)
6WSG	Clpx-clpp complex bound to ssra-tagged GFP, intermediate complex	electron microscopy	L, K, J, I, H, N, M	—	—
7MK5	Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b	ZGV	20 (best 0.85)
7MK5	Crystal structure of escherichia COLI clpp covalently inhibited by clipibicyclene	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b	ZGV	—
8E7V	Cryo-EM structure of substrate-free DNClpX.ClpP from singly capped particles	electron microscopy	H, I, J, K, L, M, N, h, i, j, k, l, m, n	—	10 (best 0.76)
8E8Q	Cryo-EM structure of substrate-free DNClpX.ClpP	electron microscopy	H, I, J, K, L, M, N, h, i, j, k, l, m, n	—	9 (best 0.75)
8E91	Cryo-EM structure of substrate-free ClpX.ClpP	electron microscopy	H, I, J, K, L, M, N, h, i, j, k, l, m, n	—	10 (best 0.77)
8ET3	Cryo-EM structure of a delivery complex containing the SspB adaptor, an ssrA-tagged substrate, and…	electron microscopy	H, I, J, K, L, M, N	—	8 (best 0.84)
8V9R	Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA…	electron microscopy	h, i, j, k, l, m, n, p, q, r, s, t, u, v	—	8 (best 0.79)
9C87	Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA…	electron microscopy	h, i, j, k, l, m, n, p, q, r, s, t, u, v	—	8 (best 0.80)
9C88	Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Translocating a Portion of a Branched-Degron…	electron microscopy	h, i, j, k, l, m, n, p, q, r, s, t, u, v	—	11 (best 0.77)
P0A6G7	AlphaFold monomer V2.0 prediction for ATP-dependent clp protease proteolytic subunit (P0A6G7)	predicted	A	—	—

Ligands

KHS · N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide · in 2 records
ZGV · 4-[(1E)-3-{[(2E,4E,6E,8S)-8-hydroxy-4-methyldeca-2,4,6-trienoyl]amino}-3-oxoprop-1-en-1-yl]azete-1(2H)-carboxylic acid · in 2 records

Experiment against prediction

6NB1 chain K against the predicted model P0A6G7: TM-score 1.00, RMSD 0.28 Å
6NB1 chain K against the predicted model P0A6G7: TM-score 1.00, RMSD 0.28 Å
6NB1 chain E against the predicted model P0A6G7: TM-score 1.00, RMSD 0.29 Å
6NB1 chain E against the predicted model P0A6G7: TM-score 1.00, RMSD 0.29 Å
6NB1 chain M against the predicted model P0A6G7: TM-score 1.00, RMSD 0.29 Å
6NB1 chain M against the predicted model P0A6G7: TM-score 1.00, RMSD 0.29 Å
6NB1 chain I against the predicted model P0A6G7: TM-score 1.00, RMSD 0.30 Å
6NB1 chain I against the predicted model P0A6G7: TM-score 1.00, RMSD 0.30 Å
6NB1 chain H against the predicted model P0A6G7: TM-score 1.00, RMSD 0.31 Å
6NB1 chain H against the predicted model P0A6G7: TM-score 1.00, RMSD 0.31 Å

Elsewhere

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