Research workbench

RNA complex of WT1 zinc finger transcription factor

Analyse RNA complex of WT1 zinc finger transcription factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WLH
Type: protein + RNA
Length: 147 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wilms tumor protein; RNA (29-mer)
UniProt: P19544
Ligands: ZN
Pockets: 3 · best druggability 0.64

Structure

solution nmr · 2 distinct chains · 39% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wilms tumor protein	protein	118	39% helix, 10% strand	P19544
B	RNA (29-mer)	rna	29	—	—

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.64	0.89	21	empty
2	170	0.63	0.85	21	empty
3	117	0.52	0.82	18	empty

Interfaces

1 interface between chains.

A–B · 1929 Å² buried · 73 hydrogen bonds · protein-nucleic

Compared structures

6WLH · RNA complex of WT1 zinc finger transcription factor · the same entry in another collection · chain A against A, TM-score 1.00
P19544 · AlphaFold monomer V2.0 prediction for wilms tumor protein (P19544) · a predicted model of the same protein · chain A against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19544
Elsewhere: RCSB PDB 6WLH · PDBe 6WLH · UniProt P19544

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