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Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex

Analyse Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6WJC
Type
protein
Length
514 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P11229, D9IEF7, Q8QGR0
Ligands
Y01, ACM, OIN

Structure

x-ray diffraction · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein445—P11229, D9IEF7
C—protein69—Q8QGR0

Ligands and binding sites

  • Y01 · Cholesterol hemisuccinate · ligand · 4 copies · chains A
  • ACM · Acetamide · ligand · chains A
  • OIN · (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2R)-3-hydroxy-2-phenylpropanoate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6WJC · Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex · the same entry in another collection · chain A against A, TM-score 1.00
  • Q8QGR0 · AlphaFold monomer V2.0 prediction for muscarinic toxin 7 (Q8QGR0) · a predicted model of the same protein · chain C against A, TM-score 0.83
  • P11229 · AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M1 (P11229) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

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