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Acyl carrier protein (acp) domain bound to dehydratase (dh) domain in fungal fatty acid synthase (fas)
Analyse Acyl carrier protein (acp) domain bound to dehydratase (dh) domain in fungal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WC7
- Type
- protein
- Length
- 585 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid synthase subunit beta; Fatty acid synthase subunit alpha
- EC
- 2.3.1.86, 4.2.1.59, 1.3.1.9, 2.3.1.38, 2.3.1.39, 3.1.2.14, 1.1.1.100, 2.3.1.41
- UniProt
- P07149, P19097
- Pockets
- 6 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 29% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Fatty acid synthase subunit beta (EC 2.3.1.86, 4.2.1.59, 1.3.1.9, 2.3.1.38, 2.3.1.39, 3.1.2.14) | protein | 422 | 21% helix, 16% strand | P07149 |
| A | Fatty acid synthase subunit alpha (EC 2.3.1.86, 1.1.1.100, 2.3.1.41) | protein | 163 | 50% helix, 1% strand | P19097 |
Pockets
6 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.80 | 0.90 | 74 | empty |
| 2 | 1089 | 0.78 | 0.80 | 114 | empty |
| 3 | 732 | 0.70 | 0.77 | 74 | empty |
| 4 | 154 | 0.69 | 0.89 | 49 | empty |
| 5 | 52 | 0.53 | 0.89 | 19 | empty |
Interfaces
1 interface between chains.
- G–A · 42 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6WC7 · Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid… · the same entry in another collection · chain G against G, TM-score 1.00
- P07149 · AlphaFold monomer V2.0 prediction for fatty acid synthase subunit beta (P07149) · a predicted model of the same protein · chain G against A, TM-score 0.95
- P19097 · AlphaFold monomer V2.0 prediction for fatty acid synthase subunit alpha (P19097) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07149
- Every structure of UniProt P19097
- Elsewhere: RCSB PDB 6WC7 · PDBe 6WC7 · UniProt P07149 · UniProt P19097
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