Research workbench
The structure of the F64A, S172A mutant KEAP1-btb domain in complex with SKP1-FBXL17
Analyse The structure of the F64A, S172A mutant KEAP1-btb domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6W66
- Type
- protein
- Length
- 659 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-phase kinase-associated protein 1; F-BOX/LRR-repeat protein 17; Kelch-like…
- UniProt
- P63208, Q9UF56, Q14145
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 45% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-phase kinase-associated protein 1 | protein | 154 | 50% helix, 6% strand | P63208 |
| B | F-BOX/LRR-repeat protein 17 | protein | 375 | 42% helix, 12% strand | Q9UF56 |
| C | Kelch-like ech-associated protein 1 | protein | 130 | 49% helix, 19% strand | Q14145 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1071 | 0.77 | 0.79 | 82 | empty |
| 2 | 197 | 0.64 | 0.83 | 28 | empty |
| 3 | 154 | 0.60 | 0.84 | 28 | empty |
| 4 | 360 | 0.58 | 0.76 | 38 | empty |
| 5 | 256 | 0.56 | 0.77 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1806 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 1510 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 53 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6W66 · The structure of the F64A, S172A mutant Keap1-BTB domain in complex with SKP1-FBXL17 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UF56 · AlphaFold monomer V2.0 prediction for F-BOX/LRR-repeat protein 17 (Q9UF56) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63208
- Every structure of UniProt Q9UF56
- Every structure of UniProt Q14145
- Elsewhere: RCSB PDB 6W66 · PDBe 6W66 · UniProt P63208 · UniProt Q9UF56 · UniProt Q14145
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