Research workbench
Sthk P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with camp
Analyse Sthk P300A cyclic nucleotide-gated potassium channel in the closed state, in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VXZ
- Type
- protein
- Length
- 1,556 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sthk
- UniProt
- G0GA88
- Ligands
- PGW, CMP
- Pockets
- 20 · best druggability 0.71
Structure
electron microscopy · 1 distinct chain · 56% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Sthk | protein | 389 | 56% helix, 6% strand | G0GA88 |
Ligands and binding sites
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · ligand · 24 copies · chains A, B, D, C
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 228 | 0.71 | 0.86 | 30 | empty |
| 2 | 207 | 0.71 | 0.86 | 28 | empty |
| 3 | 224 | 0.70 | 0.86 | 25 | empty |
| 4 | 242 | 0.69 | 0.85 | 30 | empty |
| 5 | 331 | 0.68 | 0.82 | 46 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2505 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 2498 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 2497 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 2497 Ų buried · 23 hydrogen bonds · protein-protein
- B–D · 61 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6VXZ · SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0GA88
- Elsewhere: RCSB PDB 6VXZ · PDBe 6VXZ · UniProt G0GA88
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.