Research workbench
X-ray structure of alks 4230, a fusion of circularly permuted human interleukin-2 and interleukin-2 receptor alpha
Analyse X-ray structure of alks 4230, a fusion of circularly permuted human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VWU
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-2,INTERLEUKIN-2 receptor subunit alpha
- UniProt
- Q6QWN0, P60568, P01589
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-2,INTERLEUKIN-2 receptor subunit alpha | protein | 258 | 31% helix, 20% strand | Q6QWN0, P60568, P01589 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.47 | 0.80 | 21 | empty |
| 2 | 124 | 0.42 | 0.76 | 21 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6VWU · X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and… · the same entry in another collection · chain A against A, TM-score 1.00
- P01589 · AlphaFold monomer V2.0 prediction for interleukin-2 receptor subunit alpha (P01589) · a predicted model of the same protein · chain A against A, TM-score 0.48
- P60568 · AlphaFold monomer V2.0 prediction for interleukin-2 (P60568) · a predicted model of the same protein · chain A against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6QWN0
- Every structure of UniProt P60568
- Every structure of UniProt P01589
- Elsewhere: RCSB PDB 6VWU · PDBe 6VWU · UniProt Q6QWN0 · UniProt P60568 · UniProt P01589
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