UniProt P01589
Interleukin-2,Interleukin-2 receptor subunit alpha (P01589)
Interleukin-2,Interleukin-2 receptor subunit alpha (UniProt P01589): 14 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01589
- Protein
- Interleukin-2,Interleukin-2 receptor subunit alpha
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 2 · 0 records with a druggable one
Structures
15 records of P01589 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z92 | structure of interleukin-2 with its alpha receptor | x-ray diffraction | B | — | — |
| 1Z92 | Structure of interleukin-2 with its alpha receptor | x-ray diffraction | B | — | — |
| 2B5I | cytokine receptor complex | x-ray diffraction | D | — | — |
| 2B5I | Cytokine receptor complex | x-ray diffraction | D | — | — |
| 2ERJ | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | x-ray diffraction | A, E | — | — |
| 2ERJ | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | x-ray diffraction | A, E | — | — |
| 3IU3 | Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra… | x-ray diffraction | I, J, K | — | — |
| 3IU3 | Crystal structure of the Fab fragment of therapeutic antibody basiliximab in complex with il-2RA… | x-ray diffraction | I, J, K | — | — |
| 3NFP | Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra… | x-ray diffraction | I, K | — | — |
| 3NFP | Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with il-2RA… | x-ray diffraction | I, K | — | — |
| 6VWU | X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2… | x-ray diffraction | A | — | 2 (best 0.47) |
| 6VWU | X-ray structure of alks 4230, a fusion of circularly permuted human interleukin-2 and interleukin-2… | x-ray diffraction | A | — | — |
| 6YIO | Crystal structure of Fab RG6292 in complex with CD25 ecd | x-ray diffraction | B | — | — |
| 7F9W | CD25 in complex with Fab | electron microscopy | A | — | — |
| P01589 | AlphaFold monomer V2.0 prediction for interleukin-2 receptor subunit alpha (P01589) | predicted | A | — | — |
Experiment against prediction
- 7F9W chain A against the predicted model P01589: TM-score 0.94, RMSD 1.11 Å
- 2B5I chain D against the predicted model P01589: TM-score 0.94, RMSD 1.17 Å
- 2B5I chain D against the predicted model P01589: TM-score 0.94, RMSD 1.17 Å
- 2ERJ chain A against the predicted model P01589: TM-score 0.94, RMSD 1.32 Å
- 2ERJ chain A against the predicted model P01589: TM-score 0.94, RMSD 1.32 Å
- 2ERJ chain E against the predicted model P01589: TM-score 0.93, RMSD 1.34 Å
- 2ERJ chain E against the predicted model P01589: TM-score 0.93, RMSD 1.34 Å
- 1Z92 chain B against the predicted model P01589: TM-score 0.93, RMSD 1.18 Å
- 1Z92 chain B against the predicted model P01589: TM-score 0.93, RMSD 1.18 Å
- 3IU3 chain J against the predicted model P01589: TM-score 0.92, RMSD 1.33 Å
Elsewhere
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