UniProt P60568
Interleukin-2 (P60568)
Interleukin-2 (UniProt P60568): 54 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P60568
- Protein
- Interleukin-2
- Experimental structures
- 54
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 59 · 5 records with a druggable one
Structures
55 records of P60568 in the MolNFT archive: 54 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IRL | The solution structure of the F42A mutant of human interleukin 2 | solution nmr | A | — | — |
| 1IRL | The solution structure of the F42A mutant of human interleukin 2 | solution nmr | A | — | — |
| 1M47 | Crystal Structure of Human Interleukin-2 | x-ray diffraction | A | — | — |
| 1M47 | Crystal structure of human interleukin-2 | x-ray diffraction | A | — | — |
| 1M48 | Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoet… | x-ray diffraction | A, B | — | — |
| 1M48 | Crystal structure of human il-2 complexed with (R)-N-[2-[1… | x-ray diffraction | A, B | — | — |
| 1M49 | Crystal Structure of Human Interleukin-2 Complexed with SP-1985 | x-ray diffraction | A, B | — | — |
| 1M49 | Crystal structure of human interleukin-2 complexed with sp-1985 | x-ray diffraction | A, B | — | — |
| 1M4A | Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with… | x-ray diffraction | A | — | — |
| 1M4A | Crystal structure of human interleukin-2 Y31C covalently modified at C31 with… | x-ray diffraction | A | — | — |
| 1M4B | Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with… | x-ray diffraction | A | — | — |
| 1M4B | Crystal structure of human interleukin-2 K43C covalently modified at C43 with… | x-ray diffraction | A | — | — |
| 1M4C | Crystal Structure of Human Interleukin-2 | x-ray diffraction | A, B | — | — |
| 1M4C | Crystal structure of human interleukin-2 | x-ray diffraction | A, B | — | — |
| 1NBP | Crystal Structure Of Human Interleukin-2 Y31C Covalently Modified At C31 With… | x-ray diffraction | A | — | — |
| 1NBP | Crystal structure of human interleukin-2 Y31C covalently modified at C31 with… | x-ray diffraction | A | — | — |
| 1PW6 | Low Micromolar Small Molecule Inhibitor of IL-2 | x-ray diffraction | A, B | — | — |
| 1PW6 | Low micromolar small molecule inhibitor of il-2 | x-ray diffraction | A, B | — | — |
| 1PY2 | Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2 | x-ray diffraction | A, B, C, D | — | — |
| 1PY2 | Structure of a 60 nm small molecule bound to a hot spot on il-2 | x-ray diffraction | A, B, C, D | — | — |
| 1QVN | Structure of SP4160 Bound to IL-2 V69A | x-ray diffraction | A, B, C, D | — | — |
| 1QVN | Structure of SP4160 bound to il-2 V69A | x-ray diffraction | A, B, C, D | — | — |
| 1Z92 | structure of interleukin-2 with its alpha receptor | x-ray diffraction | A | — | — |
| 1Z92 | Structure of interleukin-2 with its alpha receptor | x-ray diffraction | A | — | — |
| 2B5I | cytokine receptor complex | x-ray diffraction | A | — | — |
| 2B5I | Cytokine receptor complex | x-ray diffraction | A | — | — |
| 2ERJ | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | x-ray diffraction | D, H | — | — |
| 2ERJ | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | x-ray diffraction | D, H | — | — |
| 3INK | Unraveling the structure of interleukin-2: reply | x-ray diffraction | C, D | — | — |
| 3INK | Unraveling the structure of interleukin-2: reply | x-ray diffraction | C, D | — | — |
| 3QAZ | IL-2 mutant D10 ternary complex | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h | — | — |
| 3QAZ | Il-2 mutant D10 ternary complex | x-ray diffraction | A, D, G, J, M, P, S, V, Y, b, e, h | — | — |
| 3QB1 | Interleukin-2 mutant D10 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3QB1 | Interleukin-2 mutant D10 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5LQB | Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody | x-ray diffraction | A | — | — |
| 5LQB | Complex structure of human IL2 mutant, proleukin, with Fab fragment of NARA1 antibody | x-ray diffraction | A | — | — |
| 5UTZ | Human IL-2/Fab complex | x-ray diffraction | D, A, E, I | — | 6 (best 0.68) |
| 5UTZ | Human il-2/FAB complex | x-ray diffraction | D, A, E, I | — | — |
| 6LX3 | Cryo-EM structure of human secretory immunoglobulin A | electron microscopy | A, B, C, D | — | 16 (best 0.84) |
| 6LX3 | Cryo-EM structure of human secretory immunoglobulin a | electron microscopy | A, B, C, D | — | — |
| 6LXW | Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA | electron microscopy | A, B, C, D | — | 16 (best 0.83) |
| 6LXW | Cryo-EM structure of human secretory immunoglobulin a in complex with the N-terminal domain of spsa | electron microscopy | A, B, C, D | — | — |
| 6VWU | X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2… | x-ray diffraction | A | — | 2 (best 0.47) |
| 6VWU | X-ray structure of alks 4230, a fusion of circularly permuted human interleukin-2 and interleukin-2… | x-ray diffraction | A | — | — |
| 6YE3 | Il-2 in complex with a Fab fragment from ufka-20 | x-ray diffraction | C, F, I | — | — |
| 7DR4 | Complex of anti-human IL-2 antibody and human IL-2 | x-ray diffraction | G, I, J, K | — | 11 (best 0.75) |
| 7DR4 | Complex of anti-human il-2 antibody and human il-2 | x-ray diffraction | G, I, J, K | — | — |
| 7M2G | INTERLEUKIN-2 (human) mutant P65K, C125S | x-ray diffraction | A | SO4 | — |
| 7M2G | Interleukin-2 (human) mutant P65K, C125S | x-ray diffraction | A | SO4 | — |
| 7RA9 | Designed stabil-2 SEQ1 | x-ray diffraction | A | PO4 | — |
| 7RAA | Designed stabil-2 SEQ15 | x-ray diffraction | A, B, C, D | MG | — |
| 7ZMZ | Engineered Interleukin 2 bound to CD25 receptor | x-ray diffraction | A | — | 2 (best 0.62) |
| 8SOW | Structure of the complex formed by human interleukin-2 and scFv F10 | x-ray diffraction | A | — | 3 (best 0.28) |
| 8SOZ | Structure of the complex formed by human interleukin-2 and scFv 602 | x-ray diffraction | A | — | 3 (best 0.34) |
| P60568 | AlphaFold monomer V2.0 prediction for interleukin-2 (P60568) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3QB1 chain D against the predicted model P60568: TM-score 0.97, RMSD 0.66 Å
- 3QB1 chain D against the predicted model P60568: TM-score 0.97, RMSD 0.66 Å
- 3QB1 chain G against the predicted model P60568: TM-score 0.97, RMSD 0.70 Å
- 3QB1 chain G against the predicted model P60568: TM-score 0.97, RMSD 0.70 Å
- 3QB1 chain H against the predicted model P60568: TM-score 0.97, RMSD 0.75 Å
- 3QB1 chain H against the predicted model P60568: TM-score 0.97, RMSD 0.75 Å
- 8SOZ chain A against the predicted model P60568: TM-score 0.97, RMSD 0.91 Å
- 1M49 chain B against the predicted model P60568: TM-score 0.97, RMSD 0.78 Å
- 1M49 chain B against the predicted model P60568: TM-score 0.97, RMSD 0.78 Å
- 8SOW chain A against the predicted model P60568: TM-score 0.97, RMSD 0.82 Å
Elsewhere
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