Ligand · FRB

FRB · 2-cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide

FRB, 2-cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide (C25 H33 Cl2 N7 O2, 534.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component: FRB
Formula: C25 H33 Cl2 N7 O2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

FRB in 2 structures; the first of them:

1PW6 · Low Micromolar Small Molecule Inhibitor of IL-2 · FRB A201 · binds LYS35, ARG38, MET39, THR41, PHE42, LYS43, PHE44, TYR45 and 7 more
1PW6 · Low micromolar small molecule inhibitor of il-2 · FRB A201 · binds LYS35, ARG38, MET39, THR41, PHE42, LYS43, PHE44, TYR45 and 7 more

Residues it binds most

LYS 4, PHE 4, THR 4, ALA 4, ARG 4, GLU 4, LEU 4, MET 4, PRO 4, TYR 4 (residue and the binding sites it lines).

Found with

SO4 · Sulfate ion

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