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Ligand · FRH

FRH · 5-[2,3-dichloro-4-(5-{1-[2-(2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid

FRH, 5-[2,3-dichloro-4-(5-{1-[2-(2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid (C30 H37 Cl2 N7 O6, 662.6 g/mol), in the MolNFT structures on GenesisL1: bound…

Component
FRH
Formula
C30 H37 Cl2 N7 O6
Class
ligand
Structures
2
PDB entries
1

Binding sites

FRH in 2 structures; the first of them:

  • 1PY2 · Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2 · FRH A201 · binds PRO34, LYS35, ARG38, MET39, THR41, PHE42, LYS43, PHE44 and 7 more
  • 1PY2 · Structure of a 60 nm small molecule bound to a hot spot on il-2 · FRH A201 · binds PRO34, LYS35, ARG38, MET39, THR41, PHE42, LYS43, PHE44 and 7 more

Residues it binds most

LYS 8, PHE 8, THR 8, PRO 8, ALA 8, ARG 8, GLU 8, LEU 8, MET 8, TYR 8 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion

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