Research workbench
Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils
Analyse Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VW2
- Type
- protein
- Length
- 240 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Islet amyloid polypeptide (sumo-tagged)
- UniProt
- Q12306, P10997
- Pockets
- 2 · best druggability 0.65
Structure
electron microscopy · 1 distinct chain · 0% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Islet amyloid polypeptide (sumo-tagged) | protein | 24 | 0% helix, 46% strand | Q12306, P10997 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.65 | 0.92 | 25 | empty |
| 2 | 81 | 0.59 | 0.88 | 25 | empty |
Interfaces
17 interfaces between chains.
- E–I · 939 Ų buried · 33 hydrogen bonds · protein-protein
- A–E · 938 Ų buried · 33 hydrogen bonds · protein-protein
- D–H · 938 Ų buried · 33 hydrogen bonds · protein-protein
- B–F · 937 Ų buried · 33 hydrogen bonds · protein-protein
- A–D · 936 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 6VW2 · Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils · the same entry in another collection · chain J against J, TM-score 1.00
- P10997 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P10997) · a predicted model of the same protein · chain A against A, TM-score 0.20
- Q12306 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein SMT3 (Q12306) · a predicted model of the same protein · chain A against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12306
- Every structure of UniProt P10997
- Elsewhere: RCSB PDB 6VW2 · PDBe 6VW2 · UniProt Q12306 · UniProt P10997
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