UniProt P10997
Islet amyloid polypeptide (P10997)
Islet amyloid polypeptide (UniProt P10997): 53 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P10997
- Protein
- Islet amyloid polypeptide
- Experimental structures
- 53
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 26 · 8 records with a druggable one
Structures
54 records of P10997 in the MolNFT archive: 53 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KUW | High-Resolution Structure and Localization of Amylin Nucleation Site in Detergent Micelles | solution nmr | A | — | — |
| 1KUW | High-resolution structure and localization of amylin nucleation site in detergent micelles | solution nmr | A | — | — |
| 2G48 | crystal structure of human insulin-degrading enzyme in complex with amylin | x-ray diffraction | C, D | — | — |
| 2G48 | Crystal structure of human insulin-degrading enzyme in complex with amylin | x-ray diffraction | C, D | — | — |
| 2KB8 | The dynamic alpha-helix structure of micelle-bound human amylin. | solution nmr | A | — | — |
| 2KB8 | The dynamic alpha-helix structure of micelle-bound human amylin. | solution nmr | A | — | — |
| 2L86 | Solution NMR structure of human amylin in SDS micelles at pH 7.3 | solution nmr | A | — | — |
| 2L86 | Solution NMR structure of human amylin in sds micelles at pH 7.3 | solution nmr | A | — | — |
| 3FR1 | NFLVHS segment from Islet Amyloid Polypeptide (IAPP or Amylin) | x-ray diffraction | A | — | — |
| 3FR1 | Nflvhs segment from islet amyloid polypeptide (iapp or amylin) | x-ray diffraction | A | — | — |
| 3G7V | Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein | x-ray diffraction | A, B, C, D | — | — |
| 3G7V | Islet amyloid polypeptide (iapp or amylin) fused to maltose binding protein | x-ray diffraction | A, B, C, D | — | — |
| 3G7W | Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding Protein | x-ray diffraction | A | — | — |
| 3G7W | Islet amyloid polypeptide (iapp or amylin) residues 1 to 22 fused to maltose binding protein | x-ray diffraction | A | — | — |
| 3HGZ | Crystal structure of human insulin-degrading enzyme in complex with amylin | x-ray diffraction | D, E | — | — |
| 3HGZ | Crystal structure of human insulin-degrading enzyme in complex with amylin | x-ray diffraction | D, E | — | — |
| 5K5G | Structure of human islet amyloid polypeptide in complex with an engineered binding protein | solution nmr | A | — | — |
| 5K5G | Structure of human islet amyloid polypeptide in complex with an engineered binding protein | solution nmr | A | — | — |
| 5KNZ | Human Islet Amyloid Polypeptide Segment 19-SGNNFGAILSS-29 with Early Onset S20G Mutation Determined… | electron crystallography | A | — | — |
| 5KNZ | Human islet amyloid polypeptide segment 19-sgnnfgailss-29 with early onset S20G mutation determined… | electron crystallography | A | — | — |
| 5KO0 | Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED | electron crystallography | A, B | SCN | — |
| 5KO0 | Human islet amyloid polypeptide segment 15-flvhssnnfga-25 determined by microed | electron crystallography | A, B | SCN | — |
| 5MGQ | Solution structure of oxidized and amidated human IAPP (1-37), the diabetes II peptide. | solution nmr | A | — | — |
| 5MGQ | Solution structure of oxidized and amidated human iapp (1-37), the diabetes II peptide. | solution nmr | A | — | — |
| 6UCJ | proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Open Conformer | solution nmr | A | — | — |
| 6UCJ | Proiapp in dpc micelles - two-conformer ensemble refinement, open conformer | solution nmr | A | — | — |
| 6UCK | Proiapp in dpc micelles - two-conformer ensemble refinement, bent conformer | solution nmr | A | — | — |
| 6VW2 | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 2 (best 0.65) |
| 6VW2 | Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6Y1A | Amyloid fibril structure of islet amyloid polypeptide | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | NH2 | — |
| 6ZRF | amyloid structure of amylin (IAPP - islet amyloid polypeptide) | electron microscopy | A, C, E, G, I, K, B, D, F, H, J, L | — | — |
| 6ZRF | Amyloid structure of amylin (iapp - islet amyloid polypeptide) | electron microscopy | A, C, E, G, I, K, B, D, F, H, J, L | — | — |
| 6ZRQ | Two-protofilament amyloid structure of S20G variant of human amylin (iapp - islet amyloid… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 6ZRR | three-protofilament amyloid structure of S20G variant of human amylin (IAPP - Islet Amyloid… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | 3 (best 0.72) |
| 6ZRR | Three-protofilament amyloid structure of S20G variant of human amylin (iapp - islet amyloid… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | — | — |
| 7BG0 | Fusion of mbp and the backbone of the long-acting amylin analog AM833. | x-ray diffraction | A, B, D, E | GLC | — |
| 7M61 | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 1 (best 0.24) |
| 7M61 | Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | NH2 | — |
| 7M62 | Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | NH2 | — |
| 7M64 | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 1 (best 0.45) |
| 7M64 | Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | NH2 | — |
| 7M65 | Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 2 (best 0.74) |
| 7M65 | Cryo-EM structure of human islet amyloid polypeptide (hiapp, or amylin) fibrils seeded by patient… | electron microscopy | A, B, C, D, E, F, G, H, I, J | NH2 | — |
| 7YKW | Structure of hIAPP fibril at 3.6 Angstroms resolution | electron microscopy | A, B, C, D, E, F, G, H | — | 1 (best 0.38) |
| 7YL3 | Structure of hIAPP-TF-type1 | electron microscopy | C, E, I, K, A, F, J, H, B, G, L, D | — | 3 (best 0.46) |
| 7YL7 | Structure of hIAPP-TF-type3 | electron microscopy | F, A, B, K, C, G, L, D, H, J, E, I | — | — |
| 8AWT | IAPP S20G lag-phase fibril polymorph 2PF-P | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 1 (best 0.34) |
| 8AZ0 | IAPP S20G growth-phase fibril polymorph 2PF-L | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 2 (best 0.58) |
| 8AZ1 | IAPP S20G growth-phase fibril polymorph 2PF-C | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | 1 (best 0.23) |
| 8AZ2 | IAPP S20G growth-phase fibril polymorph 3PF-CU | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | 2 (best 0.67) |
| 8AZ3 | IAPP S20G growth-phase fibril polymorph 4PF-CU | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | 2 (best 0.67) |
| 8AZ5 | IAPP S20G plateau-phase fibril polymorph 4PF-CU | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | 3 (best 0.68) |
| 8AZ7 | IAPP S20G plateau-phase fibril polymorph 4PF-LJ | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | — | 2 (best 0.62) |
| P10997 | AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P10997) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3G7W chain A against the predicted model P0AEX9: TM-score 0.94, RMSD 0.57 Å
- 3G7V chain C against the predicted model P0AEX9: TM-score 0.93, RMSD 0.50 Å
- 3G7V chain A against the predicted model P0AEX9: TM-score 0.92, RMSD 0.71 Å
- 6UCJ chain A against the predicted model P10997: TM-score 0.82, RMSD 1.57 Å
- 6UCJ chain A against the predicted model P10997: TM-score 0.82, RMSD 1.57 Å
- 2KB8 chain A against the predicted model P10997: TM-score 0.51, RMSD 1.39 Å
- 2KB8 chain A against the predicted model P10997: TM-score 0.51, RMSD 1.39 Å
- 1KUW chain A against the predicted model P10997: TM-score 0.50, RMSD 0.45 Å
- 1KUW chain A against the predicted model P10997: TM-score 0.50, RMSD 0.45 Å
- 3HGZ chain D against the predicted model P10997: TM-score 0.46, RMSD 0.54 Å
Elsewhere
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