Research workbench
Crystal structure of the human bk channel gating ring L390P mutant
Analyse Crystal structure of the human bk channel gating ring L390P mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6V5A
- Type
- protein
- Length
- 594 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-activated potassium channel subunit alpha-1
- UniProt
- Q12791
- Ligands
- CA, SO4
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium-activated potassium channel subunit alpha-1 | protein | 594 | 39% helix, 21% strand | Q12791 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 651 | 0.79 | 0.84 | 71 | empty |
| 2 | 352 | 0.70 | 0.83 | 52 | empty |
| 3 | 118 | 0.68 | 0.90 | 21 | empty |
| 4 | 266 | 0.61 | 0.80 | 38 | empty |
| 5 | 107 | 0.44 | 0.78 | 22 | empty |
Compared structures
- 6V5A · Crystal structure of the human BK channel gating ring L390P mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q12791 · AlphaFold monomer V2.0 prediction for calcium-activated potassium channel subunit alpha-1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12791
- Elsewhere: RCSB PDB 6V5A · PDBe 6V5A · UniProt Q12791
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