Research workbench
Allosteric coupling between alpha-rings of the 20S proteasome, archaea 20S proteasome singly capped with a pan complex
Analyse Allosteric coupling between alpha-rings of the 20S proteasome, archaea 20S… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UTF
- Type
- protein
- Length
- 6,013 residues
- Chains
- 28
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit beta; Proteasome subunit alpha
- EC
- 3.4.25.1
- UniProt
- P28061, P25156
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 3 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| Z, M, 1, N, 2, H, V, I, W, J, X, K, Y, L | Proteasome subunit beta (EC 3.4.25.1) | protein | 203 | 37% helix, 26% strand | P28061 |
| A, B, C, D, E, F, G | Proteasome subunit alpha (EC 3.4.25.1) | protein | 227 | 35% helix, 24% strand | P25156 |
| O, P, Q, R, S, T, U | Proteasome subunit alpha (EC 3.4.25.1) | protein | 226 | 35% helix, 24% strand | P25156 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 756 | 0.78 | 0.82 | 83 | empty |
| 2 | 729 | 0.78 | 0.82 | 72 | empty |
| 3 | 795 | 0.77 | 0.81 | 87 | empty |
| 4 | 1138 | 0.77 | 0.79 | 112 | empty |
| 5 | 1173 | 0.77 | 0.79 | 129 | empty |
Interfaces
70 interfaces between chains.
- F–G · 1437 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 1426 Ų buried · 19 hydrogen bonds · protein-protein
- A–G · 1424 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1421 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 1420 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6UTF · Allosteric coupling between alpha-rings of the 20S proteasome, archaea 20S proteasome… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28061
- Every structure of UniProt P25156
- Elsewhere: RCSB PDB 6UTF · PDBe 6UTF · UniProt P28061 · UniProt P25156
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