Research workbench

Alpha-E-catenin abd-F-actin complex

Analyse Alpha-E-catenin abd-F-actin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6UPV
Type: protein
Length: 2,201 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Catenin alpha-1; Actin, alpha skeletal muscle
UniProt: P35221, P68139
Ligands: ADP, MG
Pockets: 20 · best druggability 0.76

Structure

electron microscopy · 2 distinct chains · 39% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
M, L	Catenin alpha-1	protein	173	59% helix, 0% strand	P35221
A, B, C, D, E	Actin, alpha skeletal muscle	protein	371	30% helix, 20% strand	P68139

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 5 copies · chains A, B, C, D, E
MG · Magnesium ion · metal · 5 copies · chains A, B, C, D, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	301	0.76	0.88	53	ADP, MG
2	310	0.76	0.88	47	ADP, MG
3	291	0.76	0.88	42	ADP, MG
4	355	0.75	0.86	56	ADP, MG
5	495	0.75	0.83	51	empty

Interfaces

12 interfaces between chains.

A–L · 1227 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 1199 Å² buried · 9 hydrogen bonds · protein-protein
C–E · 1188 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 1185 Å² buried · 10 hydrogen bonds · protein-protein
M–C · 1180 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 covalent, 5 modified (covalent ligand, methylation).

Compared structures

6UPV · Alpha-E-catenin ABD-F-actin complex · the same entry in another collection · chain E against E, TM-score 1.00
P68139 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68139) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35221
Every structure of UniProt P68139
Elsewhere: RCSB PDB 6UPV · PDBe 6UPV · UniProt P35221 · UniProt P68139

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.