UniProt P68139
Actin, alpha skeletal muscle (P68139)
Actin, alpha skeletal muscle (UniProt P68139), EC 3.6.4.-: 56 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 407 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P68139
- Protein
- Actin, alpha skeletal muscle
- EC
- 3.6.4.-
- Experimental structures
- 56
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 407 · 23 records with a druggable one
Structures
57 records of P68139 in the MolNFT archive: 56 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MDU | Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1) | x-ray diffraction | B, E | — | — |
| 1MDU | Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (gs-1) | x-ray diffraction | B, E | — | — |
| 5YU8 | Cofilin decorated actin filament | electron microscopy | A, B, C, D, E | MG, ADP | 20 (best 0.84) |
| 5YU8 | Cofilin decorated actin filament | electron microscopy | A, B, C, D, E | MG, ADP | — |
| 6D8C | Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin | electron microscopy | H, J, K, L, M | ADP, MG | 20 (best 0.84) |
| 6D8C | Cryo-EM structure of flnaabd E254K bound to phalloidin-stabilized F- actin | electron microscopy | H, J, K, L, M | ADP, MG | — |
| 6DJM | Cryo-EM structure of AMPPNP-actin filaments | electron microscopy | A, B, C, D | MG, ANP | — |
| 6DJM | Cryo-EM structure of amppnp-actin filaments | electron microscopy | A, B, C, D | MG, ANP | — |
| 6DJN | Cryo-EM structure of ADP-Pi-actin filaments | electron microscopy | A, B, C, D | MG, ADP, PO4 | — |
| 6DJN | Cryo-EM structure of ADP-pi-actin filaments | electron microscopy | A, B, C, D | MG, ADP, PO4 | — |
| 6DJO | Cryo-EM structure of ADP-actin filaments | electron microscopy | A, B, C, D | MG, ADP | — |
| 6M5G | F-actin-Utrophin complex | electron microscopy | A, B, C, D, E | MG, ADP | — |
| 6M5G | F-actin-utrophin complex | electron microscopy | A, B, C, D, E | MG, ADP | — |
| 6UPV | Alpha-E-catenin ABD-F-actin complex | electron microscopy | A, B, C, D, E | ADP, MG | 20 (best 0.76) |
| 6UPV | Alpha-E-catenin abd-F-actin complex | electron microscopy | A, B, C, D, E | ADP, MG | — |
| 6UPW | Metavinculin ABD-F-actin complex | electron microscopy | C, B, A, D, E | ADP, MG | 20 (best 0.79) |
| 6UPW | Metavinculin abd-F-actin complex | electron microscopy | C, B, A, D, E | ADP, MG | — |
| 6X5Z | Bovine cardiac myosin in complex with chicken skeletal actin and human cardiac tropomyosin in the… | electron microscopy | B, A, C | ADP, MG | — |
| 7BT7 | F-actin-ADP complex structure | electron microscopy | A, B, C, D, E | MG, ADP | 17 (best 0.82) |
| 7BT7 | F-actin-ADP complex structure | electron microscopy | A, B, C, D, E | MG, ADP | — |
| 7BTE | Lifeact-F-actin complex | electron microscopy | A, C, E, G, I | MG, ADP | 20 (best 0.82) |
| 7BTE | Lifeact-F-actin complex | electron microscopy | A, C, E, G, I | ADP, MG | — |
| 7BTI | Phalloidin bound F-actin complex | electron microscopy | A, B, C, D, E | MG, ADP | — |
| 7K20 | Cryo-EM structure of pyrene-labeled ADP-actin filaments | electron microscopy | A, B, C, D | MG, ADP, 1T4 | 15 (best 0.81) |
| 7K20 | Cryo-EM structure of pyrene-labeled ADP-actin filaments | electron microscopy | A, B, C, D | MG, ADP, 1T4 | — |
| 7K21 | Cryo-EM structure of pyrene-labeled ADP-Pi-actin filaments | electron microscopy | A, B, C, D | MG, ADP, PO4, 1T4 | 14 (best 0.80) |
| 7K21 | Cryo-EM structure of pyrene-labeled ADP-pi-actin filaments | electron microscopy | A, B, C, D | MG, ADP, PO4, 1T4 | — |
| 7KCH | Myosin XI-F-actin complex | electron microscopy | G, B, C | ADP, MG | 12 (best 0.79) |
| 7KCH | Myosin XI-F-actin complex | electron microscopy | G, B, C | ADP, MG | — |
| 7R8V | Cryo-EM structure of the ADP state actin filament | electron microscopy | B, A, C, D, E | ADP, MG | 17 (best 0.82) |
| 7R8V | Cryo-EM structure of the ADP state actin filament | electron microscopy | B, A, C, D, E | ADP, MG | — |
| 7R91 | Cryo-EM structure of the rigor state wild type myosin-15-F-actin complex | electron microscopy | A, B, C | ADP | — |
| 7R94 | T-plastin-F-actin complex | electron microscopy | C, B, A, D, E | ADP, MG | — |
| 7RB8 | cryo-EM structure of the ADP state wild type myosin-15-F-actin complex | electron microscopy | A, B, C | ADP, MG | 12 (best 0.81) |
| 7RB8 | Cryo-EM structure of the ADP state wild type myosin-15-F-actin complex | electron microscopy | A, B, C | ADP | — |
| 7RB9 | Cryo-EM structure of the rigor state Jordan myosin-15-F-actin complex | electron microscopy | B, A, C | ADP, MG | 12 (best 0.85) |
| 7RB9 | Cryo-EM structure of the rigor state jordan myosin-15-F-actin complex | electron microscopy | B, A, C | ADP, MG | — |
| 7SX8 | T-Plastin-F-actin complex, parallel bundled state | electron microscopy | C, B, A, H, G, E | ADP, MG | 18 (best 0.83) |
| 7SX8 | T-plastin-F-actin complex, parallel bundled state | electron microscopy | C, B, A, H, G, E | ADP, MG | — |
| 7SX9 | T-plastin-F-actin complex, anti-parallel bundled state | electron microscopy | B, A, C, G, E, H | ADP, MG | — |
| 7SXA | T-plastin-F-actin complex, pre-bundling intermediate state | electron microscopy | C, B, D | ADP, MG | — |
| 7UDT | cryo-EM structure of the rigor state wild type myosin-15-F-actin complex (symmetry expansion and… | electron microscopy | A, B, C | ADP | — |
| 7UDT | Cryo-EM structure of the rigor state wild type myosin-15-F-actin complex (symmetry expansion and… | electron microscopy | A, B, C | ADP | — |
| 7UDU | Cryo-EM structure of the ADP state wild type myosin-15-F-actin complex (symmetry expansion and… | electron microscopy | A, B, C | ADP | — |
| 7W51 | Crystal structure of fragmin domain-1 in complex with actin (ADP-form) | x-ray diffraction | A | ADP, CA | — |
| 7YNE | Crystal structure of fragmin domain-1 (1-160) in complex with G-form actin | x-ray diffraction | A, C, E, G | ADP, CA, NA | 20 (best 0.76) |
| 8C4C | F-actin decorated by SipA497-669 | electron microscopy | A, B, C, D, E, F, G, H | ADP, PO4, MG | 20 (best 0.87) |
| 8C4E | F-actin decorated by SipA426-685 | electron microscopy | A, B, C, D, E, F, G, H | ADP, PO4, MG | 20 (best 0.89) |
| 8D13 | Helical ADP-F-actin | electron microscopy | A, B, C | ADP, MG | 11 (best 0.79) |
| 8D16 | Bent ADP-Pi-F-actin | electron microscopy | A, B, C, D, E, F, G | ADP, MG, PO4 | 20 (best 0.82) |
| 8D17 | Straight ADP-F-actin 1 | electron microscopy | A, B, C, D, E, F, G | ADP, MG | 20 (best 0.82) |
| 8D18 | Straight ADP-F-actin 2 | electron microscopy | A, B, C, D, E, F, G | ADP, MG | 20 (best 0.79) |
| 8E9B | Cryo-EM structure of S. pombe Arp2/3 complex in the branch junction | electron microscopy | M, N, O, P, Q, R, H, I | MG, ADP | 16 (best 0.82) |
| 8SYF | Homology model of Acto-HMM complex in ADP-state. Chicken smooth muscle HMM and chicken pectoralis… | electron microscopy | C, D | — | 4 (best 0.40) |
| 8VFM | Salmonella effector protein SipA decorated actin filament | electron microscopy | J, L, M, N, R, S, U, W | MG, ADP | 20 (best 0.87) |
| 9DVA | F-actin binding interface of alpha-E-catenin ABD (cadherin-catenin complex) and afadin | electron microscopy | A, B, C, D, E | ADP, MG | 19 (best 0.81) |
| P68139 | AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68139) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7YNE chain C against the predicted model P68139: TM-score 0.99, RMSD 0.81 Å
- 7YNE chain G against the predicted model P68139: TM-score 0.98, RMSD 0.92 Å
- 7YNE chain A against the predicted model P68139: TM-score 0.98, RMSD 1.02 Å
- 7YNE chain E against the predicted model P68139: TM-score 0.98, RMSD 1.04 Å
- 1MDU chain E against the predicted model P68139: TM-score 0.98, RMSD 1.31 Å
- 1MDU chain E against the predicted model P68139: TM-score 0.98, RMSD 1.31 Å
- 7W51 chain A against the predicted model P68139: TM-score 0.97, RMSD 1.27 Å
- 1MDU chain B against the predicted model P68139: TM-score 0.97, RMSD 1.33 Å
- 1MDU chain B against the predicted model P68139: TM-score 0.97, RMSD 1.33 Å
- 8C4E chain E against the predicted model P68139: TM-score 0.96, RMSD 1.41 Å
Elsewhere
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