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Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the apo, closed state

Analyse Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6U9V
Type
protein
Length
1,680 residues
Chains
3
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q64663
Ligands
PLM, GDP, Q3G, NAG, GLC, ZN

Structure

electron microscopy · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, B, C—protein560—Q64663

Ligands and binding sites

  • PLM · Palmitic acid · ligand · 18 copies · chains A, B, C
  • GDP · Guanosine-5'-diphosphate · ligand · 3 copies · chains A, B, C
  • Q3G · O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy) propoxy](hydroxy)phosphoryl]-D-serine · ligand · 3 copies · chains A, B, C
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 21 copies · chains A, B, C
  • GLC · alpha-D-glucopyranose · sugar · 6 copies · chains A, B, C
  • ZN · Zinc ion · metal · 6 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6U9V · Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the apo… · the same entry in another collection · chain A against A, TM-score 1.00
  • Q64663 · AlphaFold monomer V2.0 prediction for P2X purinoceptor 7 (Q64663) · a predicted model of the same protein · chain A against A, TM-score 0.73

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