UniProt Q64663
P2X purinoceptor 7 (Q64663)
P2X purinoceptor 7 (UniProt Q64663): 13 experimental structures on GenesisL1, 14 ligands bound, 200 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q64663
- Protein
- P2X purinoceptor 7
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 200 · 10 records with a druggable one
Structures
13 records of Q64663 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6U9V | Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the apo, closed state | electron microscopy | A, B, C | NAG, GLC, GDP, ZN, Q3G, PLM | 20 (best 0.85) |
| 6U9V | Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the apo, closed state | electron microscopy | A, B, C | NAG, GLC, GDP, ZN, Q3G, PLM | — |
| 6U9W | Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open… | electron microscopy | A, B, C | NAG, ZN, GDP, Q3G, PLM, ATP | 20 (best 0.88) |
| 6U9W | Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open… | electron microscopy | A, B, C | NAG, ZN, GDP, Q3G, PLM, ATP | — |
| 8TR5 | Cryo-EM structure of the rat P2X7 receptor in the apo closed state | electron microscopy | A, B, C | GDP, ZN, NAG, PLM, NA | 20 (best 0.88) |
| 8TR6 | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079 | electron microscopy | A, B, C | KE3, GDP, ZN, NAG, PLM, NA | 20 (best 0.88) |
| 8TR8 | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056 | electron microscopy | A, B, C | KEI, GDP, ZN, NAG, PLM, NA | 20 (best 0.88) |
| 8TRA | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160 | electron microscopy | A, B, C | KF0, GDP, ZN, NAG, PLM, NA | 20 (best 0.90) |
| 8TRB | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567 | electron microscopy | A, B, C | 7RV, GDP, ZN, NAG, PLM, NA | 20 (best 0.88) |
| 8TRJ | Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP | electron microscopy | A, B, C | KD9, GDP, ZN, NAG, PLM | 20 (best 0.88) |
| 8TRK | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue | electron microscopy | A, C, B | KFM, GDP, ZN, NAG, PLM | 20 (best 0.85) |
| 8V4S | Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium | electron microscopy | A, B, C | GDP, ZN, NAG, PLM | 20 (best 0.84) |
| Q64663 | AlphaFold monomer V2.0 prediction for P2X purinoceptor 7 (Q64663) | — | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 12 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- PLM · Palmitic acid · in 12 records
- ZN · Zinc ion · in 12 records
- NA · Sodium ion · in 5 records
- Q3G · O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy) propoxy](hydroxy)phosphoryl]-D-serine · in 4 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- GLC · alpha-D-glucopyranose · in 2 records
- 7RV · N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide · in 1 record
- KD9 · 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate) · in 1 record
- KE3 · 3-{[(5R)-5-(2,3-dichlorophenyl)tetrazolidin-1-yl]methyl}pyridine · in 1 record
- KEI · N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide · in 1 record
- KF0 · N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide · in 1 record
- KFM · 4,4',4''-[methanetriyltris(4,1-phenyleneazanediyl)]tri(benzene-1-sulfonic acid) · in 1 record
Elsewhere
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