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Crystal structure of rsgcamp in the off state (illuminated)

Analyse Crystal structure of rsgcamp in the off state (illuminated) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TV7
Type: protein
Length: 397 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rsgcamp
Ligands: PIA, NA, CA
Pockets: 3 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rsgcamp	protein	397	31% helix, 31% strand	—

Ligands and binding sites

PIA · [(4Z)-2-[(1S)-1-aminoethyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid · ligand · chains A
NA · Sodium ion · metal · 5 copies · chains A
CA · Calcium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.81	0.94	41	PIA
2	388	0.65	0.79	61	empty
3	127	0.50	0.80	20	empty

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

6TV7 · Crystal structure of rsGCaMP in the OFF state (illuminated) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6TV7 · PDBe 6TV7

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