PIA · [(4Z)-2-[(1S)-1-aminoethyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid

Binding sites

PIA in 33 structures; the first of them:

• 5O89 · Crystal structure of RSEGFP2 in the fluorescent on-state determined by sfx · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 9 more
• 5O8A · Crystal structure of RSEGFP2 in the non-fluorescent off-state determined by sfx · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 7 more
• 5O8B · Difference-refined excited-state structure of RSEGFP2 1PS following 400NM-laser… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 8 more
• 5O8C · Composite structure of RSEGFP2 1PS following 400NM-laser irradiation of the off-state. · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 7 more
• 6AS9 · Filamentous assembly of green fluorescent protein supported by a C- terminal fusion of… · PIA A66 · binds VAL61, THR62, THR63, PHE64, LEU68, GLN69, GLN94, ARG96 and 11 more
• 6FP7 · MTFP1/DARPIN 1238_E11 complex in space group P6522 · PIA A62 · binds THR58, THR59, ALA60, PHE61, ASN65, ARG66, TRP89, ARG91 and 6 more
• 6FP8 · MTFP1/DARPIN 1238_E11 complex in space group C2 · PIA A62 · binds THR58, THR59, ALA60, PHE61, ASN65, ARG66, TRP89, ARG91 and 6 more
• 6GO8 · Structure of GFPMUT2 crystallized at pH 6 · PIA A66 · binds VAL61, THR62, THR63, PHE64, LEU68, GLN69, GLN94, ARG96 and 8 more
• 6GO9 · Structure of GFPMUT2 crystallized at pH 6 and transferred to pH 7 · PIA A66 · binds VAL61, THR62, THR63, PHE64, LEU68, GLN69, GLN94, ARG96 and 8 more
• 6GQG · Structure of GFPMUT2 crystallized at pH 8.5 · PIA A66 · binds VAL61, THR62, THR63, PHE64, LEU68, GLN69, GLN94, ARG96 and 11 more
• 6GQH · Structure of GFPMUT2 crystallized at pH 8.5 and transferred to pH 6 · PIA A66 · binds VAL61, THR62, THR63, PHE64, LEU68, GLN69, GLN94, ARG96 and 10 more
• 6GRM · Structure of GFPMUT2 crystallized at pH 6 and transferred to pH 9 · PIA A66 · binds VAL61, THR62, THR63, PHE64, LEU68, GLN69, GLN94, ARG96 and 9 more
• 6QSL · Mtfp* closed conformation: I197C-Y200H-Y204H mutant for enhanced metal binding · PIA A62 · binds THR58, THR59, ALA60, PHE61, ASN65, ARG66, TRP89, ARG91 and 6 more
• 6QSM · Mtfp* open conformation: I197C-Y200H-Y204H mutant for enhanced metal binding · PIA A62 · binds ASN38, THR58, THR59, ALA60, PHE61, ASN65, ARG66, TRP89 and 7 more
• 6S68 · Structure of the fluorescent protein AAUSFP2 from aequorea cf. australis at pH 7.6 · PIA A66 · binds ILE61, CYS62, SER63, MET64, ALA68, LEU69, GLN92, ARG94 and 8 more
• 6T39 · Crystal structure of RSEGFP2 in its off-state determined by sfx · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 7 more
• 6T3A · Difference-refined structure of RSEGFP2 10 ns following 400-nm laser irradiation of the… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 8 more
• 6TV7 · Crystal structure of rsgcamp in the off state (illuminated) · PIA A224 · binds VAL63, PHE78, ILE80, VAL116, LEU133, GLU135, LEU202, VAL219 and 9 more
• 6YA9 · Crystal structure of rsgcamp in the on state (non-illuminated) · PIA A224 · binds VAL63, PHE78, ILE80, VAL116, LEU133, GLU135, VAL219, THR220 and 8 more
• 6ZSM · Crystal structure of rsgcamp double mutant ILE80HIS/VAL116ILE in the on state… · PIA A224 · binds VAL63, PHE78, HIS80, ILE116, LEU133, GLU135, VAL219, THR220 and 8 more
• 6ZSN · Crystal structure of rsgcamp double mutant ILE80HIS/VAL116ILE in the off state… · PIA A224 · binds VAL63, PHE78, HIS80, ILE116, LEU133, GLU135, LEU202, VAL219 and 8 more
• 7AMB · Crystal structure of RSFOLDER2 in its fluorescent on-state · PIA A68 · binds LEU43, VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95 and 10 more
• 7AMF · Crystal structure of RSFOLDER2 in its non-fluorescent off-state · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 9 more
• 7AMU · Crystal structure of RSEGFP2 T204A in its fluorescent on-state · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 10 more
• 7AUG · Crystal structure of RSGCAMP1.3 in the on state · PIA A224 · binds VAL63, PHE78, PHE80, THR116, SER118, LEU133, GLU135, VAL219 and 9 more
• 7O7C · Crystal structure of RSEGFP2 mutant V151A in the non-fluorescent off- state determined by… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 9 more
• 7O7D · Crystal structure of RSEGFP2 mutant V151A in the fluorescent on-state determined by… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 8 more
• 7O7E · Crystal structure of RSEGFP2 mutant V151L in the fluorescent on-state determined by… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 8 more
• 7O7H · Crystal structure of RSEGFP2 mutant V151L in the non-fluorescent off- state determined by… · PIA A68 · binds LEU45, VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95 and 8 more
• 7O7U · Crystal structure of RSEGFP2 in the non-fluorescent off-state determined by serial… · PIA A68 · binds LEU45, VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95 and 8 more
• 7O7V · Crystal structure of RSEGFP2 mutant V151A in the fluorescent on-state determined by… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 7 more
• 7O7W · Crystal structure of RSEGFP2 mutant V151L in the non-fluorescent off- state the… · PIA A68 · binds VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95, ARG97 and 8 more
• 7O7X · Crystal structure of RSEGFP2 mutant V151A in the non-fluorescent off- state determined by… · PIA A68 · binds LEU45, VAL62, THR63, THR64, LEU65, VAL69, LEU70, GLN95 and 8 more

Residues it binds most

LEU 35, VAL 35, THR 39, ARG 39, GLN 35, ASN 38, GLU 39, HIS 29, ILE 24, PHE 23 (residue and the binding sites it lines).

Found with

• CA · Calcium ion
• GOL · Glycerol
• MPD · (4S)-2-methyl-2,4-pentanediol
• SO4 · Sulfate ion
• EDO · 1,2-ethanediol
• FMT · Formic acid
• NA · Sodium ion
• MRD · (4R)-2-methylpentane-2,4-diol
• ACT · Acetate ion