N-terminally truncated hyoscyamine 6-hydroxylase (TH6H) in complex with N-oxalylglycine and hyoscyamine

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).

Ligands and binding sites

• OGA · N-oxalylglycine · ligand · chains A
• HYO · [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate · ligand · chains A
• SR · Strontium ion · metal · chains A
• NI · Nickel (II) ion · metal · chains A
• NA · Sodium ion · metal · chains A
• UNX · Unknown atom or ion · ion · 3 copies · chains A
• EDO · 1,2-ethanediol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 6TTN · N-terminally truncated hyoscyamine 6-hydroxylase (tH6H) in complex with N-oxalylglycine… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q6EZB3
• Elsewhere: RCSB PDB 6TTN · PDBe 6TTN · UniProt Q6EZB3