Research workbench
Human 14-3-3 sigma fused to the STARD1 peptide including phosphoserine-57
Analyse Human 14-3-3 sigma fused to the STARD1 peptide including phosphoserine-57 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6T5H
- Type
- protein
- Length
- 475 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein SIGMA,STEROIDOGENIC acute regulatory protein, mitochondrial
- UniProt
- P31947, P49675
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein SIGMA,STEROIDOGENIC acute regulatory protein, mitochondrial | protein | 234 | 81% helix, 0% strand | P31947, P49675 |
| B | 14-3-3 protein SIGMA,STEROIDOGENIC acute regulatory protein, mitochondrial | protein | 241 | 80% helix, 0% strand | P31947, P49675 |
Ligands and binding sites
- PGE · Triethylene glycol · additive · 3 copies · chains A, B
- IMD · Imidazole · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 178 | 0.54 | 0.78 | 19 | IMD |
| 2 | 183 | 0.54 | 0.79 | 26 | empty |
| 3 | 172 | 0.53 | 0.78 | 26 | empty |
| 4 | 141 | 0.40 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1505 Ų buried · 36 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6T5H · Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 · the same entry in another collection · chain A against A, TM-score 1.00
- P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P49675 · AlphaFold monomer V2.0 prediction for steroidogenic acute regulatory protein… · a predicted model of the same protein · chain B against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31947
- Every structure of UniProt P49675
- Elsewhere: RCSB PDB 6T5H · PDBe 6T5H · UniProt P31947 · UniProt P49675
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