Research workbench
Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer
Analyse Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SO5
- Type
- protein
- Length
- 1,097 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATPase ASNA1; Tail-anchored protein insertion receptor wrb; Calcium signal-modulating…
- EC
- 3.6.-.-
- UniProt
- O43681, O00258, P49069
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 60% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATPase ASNA1 (EC 3.6.-.-) | protein | 313 | 53% helix, 9% strand | O43681 |
| B | ATPase ASNA1 (EC 3.6.-.-) | protein | 292 | 43% helix, 12% strand | O43681 |
| C, D | Tail-anchored protein insertion receptor wrb | protein | 144 | 90% helix, 0% strand | O00258 |
| E | Calcium signal-modulating cyclophilin ligand | protein | 103 | 75% helix, 0% strand | P49069 |
| F | Calcium signal-modulating cyclophilin ligand | protein | 101 | 74% helix, 0% strand | P49069 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1098 | 0.85 | 0.85 | 96 | empty |
| 2 | 807 | 0.77 | 0.81 | 68 | empty |
| 3 | 331 | 0.75 | 0.86 | 39 | empty |
| 4 | 931 | 0.75 | 0.78 | 83 | empty |
| 5 | 371 | 0.74 | 0.85 | 44 | empty |
Interfaces
13 interfaces between chains.
- A–B · 1167 Ų buried · 7 hydrogen bonds · protein-protein
- A–E · 589 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 576 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 522 Ų buried · 10 hydrogen bonds · protein-protein
- D–E · 461 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6SO5 · Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer · the same entry in another collection · chain F against F, TM-score 1.00
- O43681 · AlphaFold monomer V2.0 prediction for ATPase GET3 (O43681) · a predicted model of the same protein · chain B against A, TM-score 0.84
- P49069 · AlphaFold monomer V2.0 prediction for calcium signal-modulating cyclophilin ligand… · a predicted model of the same protein · chain E against A, TM-score 0.82
- O00258 · AlphaFold monomer V2.0 prediction for guided entry of tail-anchored proteins factor 1… · a predicted model of the same protein · chain C against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43681
- Every structure of UniProt O00258
- Every structure of UniProt P49069
- Elsewhere: RCSB PDB 6SO5 · PDBe 6SO5 · UniProt O43681 · UniProt O00258 · UniProt P49069
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