UniProt O00258
Tail-anchored protein insertion receptor WRB (O00258)
Tail-anchored protein insertion receptor WRB (UniProt O00258): 5 experimental structures and 1 predicted model on GenesisL1, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00258
- Protein
- Tail-anchored protein insertion receptor WRB
- Experimental structures
- 5
- Predicted models
- 1
- Pockets
- 38 · 4 records with a druggable one
Structures
6 records of O00258 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6SO5 | Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer | electron microscopy | C, D | — | 9 (best 0.85) |
| 6SO5 | Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer | electron microscopy | C, D | — | 9 (best 0.85) |
| 8CQZ | Homo sapiens Get3 in complex with the Get1 cytoplasmic domain | x-ray diffraction | B | — | 1 (best 0.33) |
| 8CR1 | Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer | electron microscopy | C, D | — | 15 (best 0.86) |
| 8CR2 | Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer | electron microscopy | C, D | — | 3 (best 0.83) |
| O00258 | AlphaFold monomer V2.0 prediction for guided entry of tail-anchored proteins factor 1 (O00258) | predicted | A | — | 1 (best 0.36) |
Experiment against prediction
- 8CQZ chain B against the predicted model O00258: TM-score 0.83, RMSD 1.32 Å
- 8CR2 chain C against the predicted model O00258: TM-score 0.72, RMSD 2.90 Å
- 6SO5 chain C against the predicted model O00258: TM-score 0.71, RMSD 3.52 Å
- 6SO5 chain C against the predicted model O00258: TM-score 0.71, RMSD 3.52 Å
- 8CR1 chain C against the predicted model O00258: TM-score 0.49, RMSD 3.67 Å
- 8CR1 chain D against the predicted model O00258: TM-score 0.49, RMSD 3.67 Å
- 6SO5 chain D against the predicted model O00258: TM-score 0.67, RMSD 3.68 Å
- 6SO5 chain D against the predicted model O00258: TM-score 0.67, RMSD 3.68 Å
- 8CR2 chain D against the predicted model O00258: TM-score 0.45, RMSD 4.02 Å
- 8CR2 chain C against the predicted model P49069: TM-score 0.45, RMSD 3.08 Å
Elsewhere
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