Research workbench
DNA mismatch repair proteins MLH1 and MLH3
Analyse DNA mismatch repair proteins MLH1 and MLH3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SNS
- Type
- protein
- Length
- 473 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA mismatch repair protein MLH1; DNA mismatch repair protein MLH3
- UniProt
- P38920, Q12083
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA mismatch repair protein MLH1 | protein | 260 | 49% helix, 14% strand | P38920 |
| B | DNA mismatch repair protein MLH3 | protein | 213 | 44% helix, 18% strand | Q12083 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.43 | 0.74 | 33 | empty |
| 2 | 105 | 0.41 | 0.77 | 23 | empty |
| 3 | 59 | 0.28 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1060 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6SNS · DNA mismatch repair proteins MLH1 and MLH3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q12083 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MLH3 (Q12083) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P38920 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MLH1 (P38920) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38920
- Every structure of UniProt Q12083
- Elsewhere: RCSB PDB 6SNS · PDBe 6SNS · UniProt P38920 · UniProt Q12083
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