Research workbench
Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like kinase 1 (ALK1) at 2.3 ångström
Analyse Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SF3
- Type
- protein
- Length
- 180 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase receptor R3; Bone morphogenetic protein 10
- EC
- 2.7.11.30
- UniProt
- P37023, O95393
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase receptor R3 (EC 2.7.11.30) | protein | 76 | 7% helix, 38% strand | P37023 |
| B | Bone morphogenetic protein 10 | protein | 104 | 17% helix, 50% strand | O95393 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.72 | 0.87 | 32 | empty |
| 2 | 60 | 0.35 | 0.78 | 13 | empty |
| 3 | 67 | 0.31 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 737 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 6SF3 · Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin… · the same entry in another collection · chain A against A, TM-score 1.00
- O95393 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 10 (O95393) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P37023 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase receptor R3 (P37023) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37023
- Every structure of UniProt O95393
- Elsewhere: RCSB PDB 6SF3 · PDBe 6SF3 · UniProt P37023 · UniProt O95393
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