Research workbench
Nucleotide bound ABCB4
Analyse Nucleotide bound ABCB4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6S7P
- Type
- protein
- Length
- 1,128 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylcholine translocator ABCB4
- EC
- 7.6.2.1
- UniProt
- P21439
- Ligands
- CLR, ATP, MG
- Pockets
- 14 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 63% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) | protein | 1128 | 63% helix, 9% strand | P21439 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 8 copies · chains A
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 724 | 0.88 | 0.91 | 71 | empty |
| 2 | 591 | 0.86 | 0.91 | 78 | ATP, MG |
| 3 | 556 | 0.85 | 0.91 | 81 | ATP |
| 4 | 86 | 0.75 | 0.97 | 22 | empty |
| 5 | 330 | 0.63 | 0.79 | 36 | CLR |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21439
- Elsewhere: RCSB PDB 6S7P · PDBe 6S7P · UniProt P21439
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