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UniProt P21439

Isoform 2 of Phosphatidylcholine translocator ABCB4 (P21439)

Isoform 2 of Phosphatidylcholine translocator ABCB4 (UniProt P21439), EC 7.6.2.1: 6 experimental structures on GenesisL1, 5 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
P21439
Protein
Isoform 2 of Phosphatidylcholine translocator ABCB4
EC
7.6.2.1
Experimental structures
6
Predicted models
0
Ligands
5
Pockets
16 · 1 record with a druggable one

Structures

6 records of P21439 in the MolNFT archive: 6 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
6S7PNucleotide bound ABCB4electron microscopyAATP, MG, CLR—
7NIUNanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (apo-inward-open…electron microscopyACLR—
7NIVNanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound…electron microscopyADLP, CLR16 (best 0.90)
7NIVNanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound…electron microscopyADLP, CLR—
7NIWNanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open…electron microscopyACLR, X2N, DLP—
P21439AlphaFold monomer V2.0 prediction for phosphatidylcholine translocator ABCB4 (P21439)———

Ligands

  • CLR · Cholesterol · in 5 records
  • DLP · 1,2-dilinoleoyl-sn-glycero-3-phosphocholine · in 3 records
  • ATP · Adenosine-5'-triphosphate · in 1 record
  • MG · Magnesium ion · in 1 record
  • X2N · Posaconazole · in 1 record

Elsewhere

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