Research workbench
TEAD4 (216-434) complexed with yap peptide (60-100) and myristoate (covalently bound) at 2.1A (P41212 crystal form)
Analyse TEAD4 (216-434) complexed with yap peptide (60-100) and myristoate (covalently… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Q2X
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-3; Transcriptional coactivator YAP1
- UniProt
- Q15561, P46937
- Ligands
- MYR
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-3 | protein | 203 | 17% helix, 53% strand | Q15561 |
| L | Transcriptional coactivator YAP1 | protein | 40 | 48% helix, 0% strand | P46937 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.82 | 0.96 | 34 | MYR |
| 2 | 66 | 0.34 | 0.76 | 15 | empty |
| 3 | 53 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–L · 1293 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 lipid (myristoylation).
Compared structures
- 6Q2X · TEAD4 (216-434) complexed with yap peptide (60-100) and myristoate (covalently bound) at… · the same entry in another collection · chain A against A, TM-score 1.00
- Q15561 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q15561) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P46937 · AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) · a predicted model of the same protein · chain L against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15561
- Every structure of UniProt P46937
- Elsewhere: RCSB PDB 6Q2X · PDBe 6Q2X · UniProt Q15561 · UniProt P46937
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.