UniProt Q15561
Transcriptional enhancer factor TEF-3 (Q15561)
Transcriptional enhancer factor TEF-3 (UniProt Q15561): 37 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15561
- Protein
- Transcriptional enhancer factor TEF-3
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 67 · 18 records with a druggable one
Structures
38 records of Q15561 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GZB | Crystal Structure of Transcription Factor TEAD4 in Complex with M-CAT DNA | x-ray diffraction | A | — | — |
| 5GZB | Crystal structure of transcription factor TEAD4 in complex with M-cat DNA | x-ray diffraction | A | — | — |
| 5NO6 | TEAD4-HOXB13 complex bound to DNA | x-ray diffraction | I, N | — | 4 (best 0.59) |
| 5NO6 | TEAD4-HOXB13 complex bound to DNA | x-ray diffraction | I, N | — | — |
| 5OAQ | TEAD4 complexed with yap peptide and myristate (covalently bound) | x-ray diffraction | A | MYR | — |
| 5OAQ | TEAD4 complexed with yap peptide and myristate (covalently bound) | x-ray diffraction | A | MYR | — |
| 6GE3 | X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility… | x-ray diffraction | A | MYR | 3 (best 0.81) |
| 6GE3 | X-ray structure of TEAD4 (wildtype) complexed with yap (wildtype): the role of residual flexibility… | x-ray diffraction | A | MYR | — |
| 6GE4 | TEAD4 (216-434);E263A complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | A | MYR | 2 (best 0.83) |
| 6GE4 | TEAD4 (216-434);E263A complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | A | MYR | — |
| 6GE5 | TEAD4 (216-434);Y429F complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | A | MYR | 3 (best 0.83) |
| 6GE5 | TEAD4 (216-434);Y429F complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | A | MYR | — |
| 6GE6 | X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual… | x-ray diffraction | A | MYR, PO4 | 5 (best 0.83) |
| 6GE6 | X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(WILDTYPE): the role of residual… | x-ray diffraction | A | MYR, PO4 | — |
| 6GEC | TEAD4 (216-434) complexed with yap peptide (60-100);S94A and myristoate (covalently bound) at 1.70A… | x-ray diffraction | A | MYR | 3 (best 0.81) |
| 6GEC | TEAD4 (216-434) complexed with yap peptide (60-100);S94A and myristoate (covalently bound) at 1.70A… | x-ray diffraction | A | MYR | — |
| 6GEE | TEAD4 (216-434);E263A complexed with yap peptide (60-100); S94A and myristoate (covalently bound)… | x-ray diffraction | A | MYR | 2 (best 0.81) |
| 6GEE | TEAD4 (216-434);E263A complexed with yap peptide (60-100); S94A and myristoate (covalently bound)… | x-ray diffraction | A | MYR | — |
| 6GEG | TEAD4 (216-434);Y429F complexed with yap peptide (60-100); S94A and myristoate (covalently bound)… | x-ray diffraction | A | MYR | 3 (best 0.82) |
| 6GEG | TEAD4 (216-434);Y429F complexed with yap peptide (60-100); S94A and myristoate (covalently bound)… | x-ray diffraction | A | MYR | — |
| 6GEI | TEAD4 (216-434);E263A+Y429F complexed with yap peptide (60- 100);S94A and myristoate (covalently… | x-ray diffraction | A | MYR, PO4 | 3 (best 0.83) |
| 6GEI | TEAD4 (216-434);E263A+Y429F complexed with yap peptide (60- 100);S94A and myristoate (covalently… | x-ray diffraction | A | MYR, PO4 | — |
| 6GEK | TEAD4 (216-434);Y429F complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | A, B | MYR | 5 (best 0.83) |
| 6GEK | TEAD4 (216-434);Y429F complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | A, B | MYR | — |
| 6HIK | X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural… | x-ray diffraction | A | MYR, PO4 | 2 (best 0.83) |
| 6HIK | X-ray structure of TEAD4(Y429H) mutant) complexed with yap (wildtype): molecular and structural… | x-ray diffraction | A | MYR, PO4 | — |
| 6Q2X | TEAD4 (216-434) complexed with yap peptide (60-100) and myristoate (covalently bound) at 2.1A… | x-ray diffraction | A | MYR | 3 (best 0.82) |
| 6Q2X | TEAD4 (216-434) complexed with yap peptide (60-100) and myristoate (covalently bound) at 2.1A… | x-ray diffraction | A | MYR | — |
| 6Q36 | TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A… | x-ray diffraction | A, B | MYR, PO4 | 7 (best 0.83) |
| 6Q36 | TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A… | x-ray diffraction | A, B | 2JH, MYR, PO4 | — |
| 6SEN | TEAD4 bound to a FAM181A peptide | x-ray diffraction | A, B | SO4 | 3 (best 0.74) |
| 6SEN | TEAD4 bound to a FAM181A peptide | x-ray diffraction | A, B | NH2, SO4 | — |
| 6SEO | TEAD4 bound to a FAM181B peptide | x-ray diffraction | A | — | — |
| 6SEO | TEAD4 bound to a FAM181B peptide | x-ray diffraction | A | — | — |
| 8A8R | Crystal structure of TEAD4 in complex with YAP peptide | x-ray diffraction | A, B | MYR | 8 (best 0.84) |
| 8C17 | Crystal structure of TEAD4 in complex with peptide 1 | x-ray diffraction | A | MYR | 2 (best 0.83) |
| 8CAA | Crystal structure of TEAD4 in complex with YTP-13 | x-ray diffraction | A, B | U3F, U3O, PO4 | 5 (best 0.84) |
| Q15561 | AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q15561) | predicted | A | — | 4 (best 0.81) |
Ligands
- MYR · Myristic acid · in 28 records
- PO4 · Phosphate ion · in 9 records
- SO4 · Sulfate ion · in 2 records
- 2JH · 3-cyclobutyl-L-alanine · in 1 record
- NH2 · Amino group · in 1 record
- U3F · 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide · in 1 record
- U3O · (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid · in 1 record
Experiment against prediction
- 6GE5 chain A against the predicted model Q15561: TM-score 0.99, RMSD 0.71 Å
- 6GE5 chain A against the predicted model Q15561: TM-score 0.99, RMSD 0.71 Å
- 6Q2X chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.72 Å
- 6Q2X chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.72 Å
- 5OAQ chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.72 Å
- 5OAQ chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.72 Å
- 6GEG chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.72 Å
- 6GEG chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.72 Å
- 6GE3 chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.74 Å
- 6GE3 chain A against the predicted model Q15561: TM-score 0.98, RMSD 0.74 Å
Elsewhere
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