Research workbench
Cryo-EM structure of full-length IGF1R-IGF1 complex. only the extracellular region of the complex is resolved.
Analyse Cryo-EM structure of full-length IGF1R-IGF1 complex. only the extracellular… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PYH
- Type
- protein
- Length
- 1,648 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 1 receptor; Insulin-like growth factor I
- EC
- 2.7.10.1
- UniProt
- Q60751, P05019
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 10% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 1 receptor (EC 2.7.10.1) | protein | 793 | 9% helix, 28% strand | Q60751 |
| B | Insulin-like growth factor I | protein | 57 | 35% helix, 4% strand | P05019 |
| D | Insulin-like growth factor 1 receptor (EC 2.7.10.1) | protein | 798 | 10% helix, 27% strand | Q60751 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.79 | 0.81 | 99 | empty |
| 2 | 541 | 0.77 | 0.84 | 54 | empty |
| 3 | 72 | 0.73 | 0.96 | 27 | empty |
| 4 | 65 | 0.72 | 0.97 | 20 | empty |
| 5 | 93 | 0.71 | 0.93 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–D · 2531 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 801 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 679 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 disulfide (disulfide).
Compared structures
- 6PYH · Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q60751 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 1 receptor (Q60751) · a predicted model of the same protein · chain A against A, TM-score 0.66
- P05019 · AlphaFold monomer V2.0 prediction for insulin-like growth factor I (P05019) · a predicted model of the same protein · chain B against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60751
- Every structure of UniProt P05019
- Elsewhere: RCSB PDB 6PYH · PDBe 6PYH · UniProt Q60751 · UniProt P05019
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