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Crystal structure of human galnac-T12 bound to a diglycosylated peptide, MN2+, and udp

Analyse Crystal structure of human galnac-T12 bound to a diglycosylated peptide, MN2+… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PXU
Type: protein
Length: 1,086 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q8IXK2
Ligands: UDP, A2G, MN

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	526	—	Q8IXK2
B	—	protein	532	—	Q8IXK2
C	—	protein	13	—	—
D	—	protein	15	—	—

Ligands and binding sites

UDP · Uridine-5'-diphosphate · ligand · 2 copies · chains A, C, B, D
A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · sugar · 4 copies · chains A, C, B, D
MN · Manganese (II) ion · metal · 4 copies · chains A, B
EDO · 1,2-ethanediol · additive · 12 copies · chains A, C, B, D
GOL · Glycerol · additive · 8 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6PXU · Crystal structure of human GalNAc-T12 bound to a diglycosylated peptide, Mn2+, and UDP · the same entry in another collection · chain A against A, TM-score 1.00
Q8IXK2 · AlphaFold monomer V2.0 prediction for polypeptide N-acetylgalactosaminyltransferase 12… · a predicted model of the same protein · chain A against A, TM-score 1.00

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Every structure of UniProt Q8IXK2
Elsewhere: RCSB PDB 6PXU · PDBe 6PXU · UniProt Q8IXK2

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