Research workbench
N-terminal SH2 domain of the P120RASGAP bound to a P190RHOGAP phosphotyrosine peptide
Analyse N-terminal SH2 domain of the P120RASGAP bound to a P190RHOGAP phosphotyrosine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PXC
- Type
- protein
- Length
- 116 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS GTPase-activating protein 1; Phosphopeptide of P190RHOGAP
- UniProt
- P20936
- Ligands
- ACE
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS GTPase-activating protein 1 | protein | 104 | 24% helix, 37% strand | P20936 |
| U | Phosphopeptide of P190RHOGAP | protein | 12 | 0% helix, 8% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains U
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–U · 686 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 6PXC · N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide · the same entry in another collection · chain U against U, TM-score 1.00
- P20936 · AlphaFold monomer V2.0 prediction for RAS GTPase-activating protein 1 (P20936) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20936
- Elsewhere: RCSB PDB 6PXC · PDBe 6PXC · UniProt P20936
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