Research workbench
Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees celsius
Analyse Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PVO
- Type
- protein
- Length
- 2,576 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8K424
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 51% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 3 | protein | 644 | 51% helix, 2% strand | Q8K424 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 885 | 0.85 | 0.86 | 92 | empty |
| 2 | 385 | 0.76 | 0.86 | 51 | empty |
| 3 | 378 | 0.76 | 0.85 | 50 | empty |
| 4 | 87 | 0.75 | 0.97 | 27 | empty |
| 5 | 351 | 0.75 | 0.86 | 53 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2869 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 2822 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 2820 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2793 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 13 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6PVO · Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees Celsius · the same entry in another collection · chain A against A, TM-score 1.00
- Q8K424 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K424
- Elsewhere: RCSB PDB 6PVO · PDBe 6PVO · UniProt Q8K424
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