Research workbench
Crystal structure of mavc in complex with ub-UBE2N
Analyse Crystal structure of mavc in complex with ub-UBE2N in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P5B
- Type
- protein
- Length
- 613 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mavc; Ubiquitin-conjugating enzyme E2 N; Ubiquitin
- EC
- 2.3.2.23
- UniProt
- A0A2S6F4I5, P61088, P0CG48
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mavc | protein | 388 | 51% helix, 14% strand | A0A2S6F4I5 |
| C | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) | protein | 150 | 32% helix, 19% strand | P61088 |
| E | Ubiquitin | protein | 75 | 24% helix, 32% strand | P0CG48 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.78 | 0.87 | 61 | empty |
| 2 | 1004 | 0.78 | 0.80 | 98 | empty |
| 3 | 220 | 0.53 | 0.77 | 39 | empty |
| 4 | 114 | 0.39 | 0.75 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1401 Ų buried · 10 hydrogen bonds · protein-protein
- A–E · 1311 Ų buried · 28 hydrogen bonds · protein-protein
- C–E · 248 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2S6F4I5
- Every structure of UniProt P61088
- Every structure of UniProt P0CG48
- Elsewhere: RCSB PDB 6P5B · PDBe 6P5B · UniProt A0A2S6F4I5 · UniProt P61088 · UniProt P0CG48
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.