Research workbench
Crystal structure of ternary DNA complex "FX2" containing E. COLI fis and phage lambda xis
Analyse Crystal structure of ternary DNA complex "FX2" containing E. COLI fis and phage… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P0S
- Type
- protein + DNA
- Length
- 271 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein fis; DNA (27-mer), FX1-2; Excisionase
- UniProt
- P0A6R3, P03699
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 5 distinct chains · 55% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-binding protein fis | protein | 83 | 63% helix, 5% strand | P0A6R3 |
| B | DNA-binding protein fis | protein | 82 | 63% helix, 5% strand | P0A6R3 |
| C | DNA (27-mer), FX1-2 | dna | 27 | — | — |
| D | DNA (27-mer), FX1-2 | dna | 27 | — | — |
| E | Excisionase | protein | 52 | 29% helix, 27% strand | P03699 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 429 | 0.62 | 0.77 | 35 | empty |
| 2 | 256 | 0.61 | 0.81 | 39 | empty |
| 3 | 52 | 0.39 | 0.81 | 11 | empty |
| 4 | 81 | 0.37 | 0.77 | 15 | empty |
| 5 | 85 | 0.31 | 0.74 | 16 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2106 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1202 Ų buried · 111 hydrogen bonds · nucleic-nucleic
- C–E · 448 Ų buried · 11 hydrogen bonds · protein-nucleic
- D–E · 431 Ų buried · 7 hydrogen bonds · protein-nucleic
- B–D · 297 Ų buried · 4 hydrogen bonds · protein-nucleic
Compared structures
- 6P0S · Crystal structure of ternary DNA complex FX2" containing E. coli Fis and phage lambda Xis" · the same entry in another collection · chain B against B, TM-score 1.00
- P0A6R3 · AlphaFold monomer V2.0 prediction for DNA-binding protein fis (P0A6R3) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6R3
- Every structure of UniProt P03699
- Elsewhere: RCSB PDB 6P0S · PDBe 6P0S · UniProt P0A6R3 · UniProt P03699
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