Research workbench
NHTMEM16 L302A +CA2+ in nanodiscs
Analyse NHTMEM16 L302A +CA2+ in nanodiscs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OY3
- Type
- protein
- Length
- 1,188 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NHTMEM16
- UniProt
- C7Z7K1
- Ligands
- CA
- Pockets
- 19 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 57% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | NHTMEM16 | protein | 594 | 57% helix, 3% strand | C7Z7K1 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 616 | 0.76 | 0.82 | 65 | CA |
| 2 | 557 | 0.75 | 0.82 | 58 | CA |
| 3 | 585 | 0.73 | 0.81 | 73 | empty |
| 4 | 389 | 0.67 | 0.80 | 35 | empty |
| 5 | 419 | 0.67 | 0.79 | 42 | empty |
Interfaces
1 interface between chains.
- B–A · 2766 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6OY3 · nhTMEM16 L302A +Ca2+ in nanodiscs · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7Z7K1
- Elsewhere: RCSB PDB 6OY3 · PDBe 6OY3 · UniProt C7Z7K1
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