Research workbench
Cryo-EM structure of the yeast CTF3 complex
Analyse Cryo-EM structure of the yeast CTF3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OUA
- Type
- protein
- Length
- 637 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inner kinetochore subunit CTF3; Inner kinetochore subunit MCM16; Inner kinetochore…
- UniProt
- Q12748, Q12262, P47167
- Pockets
- 12 · best druggability 0.60
Structure
electron microscopy · 3 distinct chains · 53% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I | Inner kinetochore subunit CTF3 | protein | 382 | 46% helix, 0% strand | Q12748 |
| H | Inner kinetochore subunit MCM16 | protein | 131 | 61% helix, 0% strand | Q12262 |
| K | Inner kinetochore subunit MCM22 | protein | 124 | 66% helix, 0% strand | P47167 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.60 | 0.87 | 25 | empty |
| 2 | 315 | 0.59 | 0.77 | 43 | empty |
| 3 | 258 | 0.56 | 0.77 | 33 | empty |
| 4 | 176 | 0.54 | 0.79 | 26 | empty |
| 5 | 92 | 0.47 | 0.81 | 15 | empty |
Interfaces
3 interfaces between chains.
- H–K · 3659 Ų buried · 19 hydrogen bonds · protein-protein
- I–H · 2766 Ų buried · 19 hydrogen bonds · protein-protein
- I–K · 1499 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6OUA · Cryo-EM structure of the yeast Ctf3 complex · the same entry in another collection · chain I against I, TM-score 1.00
- Q12748 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit CTF3 (Q12748) · a predicted model of the same protein · chain I against A, TM-score 0.94
- Q12262 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM16 (Q12262) · a predicted model of the same protein · chain H against A, TM-score 0.88
- P47167 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM22 (P47167) · a predicted model of the same protein · chain K against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12748
- Every structure of UniProt Q12262
- Every structure of UniProt P47167
- Elsewhere: RCSB PDB 6OUA · PDBe 6OUA · UniProt Q12748 · UniProt Q12262 · UniProt P47167
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