Research workbench
Monomer of a cation channel
Analyse Monomer of a cation channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O5B
- Type
- protein
- Length
- 1,620 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium uniporter protein, mitochondrial; Essential mcu regulator, mitochondrial
- UniProt
- Q8NE86, Q9H4I9
- Ligands
- CA
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 7 distinct chains · 54% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| J, K, L, I | Calcium uniporter protein, mitochondrial | protein | 91 | 11% helix, 38% strand | Q8NE86 |
| E | Calcium uniporter protein, mitochondrial | protein | 270 | 57% helix, 12% strand | Q8NE86 |
| F, D, B | Essential mcu regulator, mitochondrial | protein | 49 | 61% helix, 4% strand | Q9H4I9 |
| C | Calcium uniporter protein, mitochondrial | protein | 268 | 57% helix, 13% strand | Q8NE86 |
| A | Calcium uniporter protein, mitochondrial | protein | 273 | 58% helix, 11% strand | Q8NE86 |
| G | Calcium uniporter protein, mitochondrial | protein | 250 | 60% helix, 10% strand | Q8NE86 |
| H | Essential mcu regulator, mitochondrial | protein | 48 | 54% helix, 4% strand | Q9H4I9 |
Ligands and binding sites
- CA · Calcium ion · metal · chains E, C, A, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1006 | 0.75 | 0.78 | 67 | empty |
| 2 | 714 | 0.75 | 0.80 | 61 | empty |
| 3 | 615 | 0.73 | 0.80 | 47 | CA |
| 4 | 51 | 0.71 | 0.97 | 20 | empty |
| 5 | 259 | 0.61 | 0.81 | 27 | empty |
Interfaces
23 interfaces between chains.
- E–A · 2401 Ų buried · 13 hydrogen bonds · protein-protein
- C–A · 2116 Ų buried · 15 hydrogen bonds · protein-protein
- C–G · 1738 Ų buried · 7 hydrogen bonds · protein-protein
- E–G · 1688 Ų buried · 12 hydrogen bonds · protein-protein
- E–C · 1445 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6O5B · Monomer of a cation channel · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NE86
- Every structure of UniProt Q9H4I9
- Elsewhere: RCSB PDB 6O5B · PDBe 6O5B · UniProt Q8NE86 · UniProt Q9H4I9
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