Research workbench
Human mcu-emre complex, dimer of channel
Analyse Human mcu-emre complex, dimer of channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O58
- Type
- protein
- Length
- 2,512 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium uniporter protein, mitochondrial; Essential mcu regulator, mitochondrial
- UniProt
- Q8NE86, Q9H4I9
- Ligands
- CA
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 6 distinct chains · 60% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K, C | Calcium uniporter protein, mitochondrial | protein | 268 | 60% helix, 12% strand | Q8NE86 |
| L, N, J, D, B, F | Essential mcu regulator, mitochondrial | protein | 49 | 55% helix, 0% strand | Q9H4I9 |
| O, G | Calcium uniporter protein, mitochondrial | protein | 250 | 62% helix, 11% strand | Q8NE86 |
| P, H | Essential mcu regulator, mitochondrial | protein | 48 | 60% helix, 4% strand | Q9H4I9 |
| M, E | Calcium uniporter protein, mitochondrial | protein | 270 | 58% helix, 11% strand | Q8NE86 |
| I, A | Calcium uniporter protein, mitochondrial | protein | 273 | 60% helix, 12% strand | Q8NE86 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains K, O, M, I, G, C, A, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.75 | 0.96 | 21 | empty |
| 2 | 140 | 0.75 | 0.93 | 35 | empty |
| 3 | 1179 | 0.74 | 0.77 | 98 | empty |
| 4 | 876 | 0.73 | 0.78 | 59 | empty |
| 5 | 586 | 0.73 | 0.80 | 50 | empty |
Interfaces
35 interfaces between chains.
- M–I · 2401 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 2322 Ų buried · 12 hydrogen bonds · protein-protein
- C–A · 2138 Ų buried · 16 hydrogen bonds · protein-protein
- K–I · 2137 Ų buried · 19 hydrogen bonds · protein-protein
- K–O · 1730 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6O58 · Human MCU-EMRE complex, dimer of channel · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NE86
- Every structure of UniProt Q9H4I9
- Elsewhere: RCSB PDB 6O58 · PDBe 6O58 · UniProt Q8NE86 · UniProt Q9H4I9
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