Research workbench
Crystal structure of E. COLI fumarase C bound to citrate at 1.53 ångström resolution
Analyse Crystal structure of E. COLI fumarase C bound to citrate at 1.53 ångström… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NZ9
- Type
- protein
- Length
- 915 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fumarate hydratase class II
- EC
- 4.2.1.2
- UniProt
- P05042
- Pockets
- 5 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fumarate hydratase class II (EC 4.2.1.2) | protein | 456 | 62% helix, 8% strand | P05042 |
| B | Fumarate hydratase class II (EC 4.2.1.2) | protein | 459 | 62% helix, 8% strand | P05042 |
Ligands and binding sites
- CIT · Citric acid · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.53 | 0.74 | 37 | empty |
| 2 | 211 | 0.44 | 0.73 | 26 | empty |
| 3 | 93 | 0.36 | 0.75 | 19 | empty |
| 4 | 63 | 0.31 | 0.75 | 12 | empty |
| 5 | 54 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2889 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 6NZ9 · Crystal structure of E. coli fumarase C bound to citrate at 1.53 angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P05042 · AlphaFold monomer V2.0 prediction for fumarate hydratase class II (P05042) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05042
- Elsewhere: RCSB PDB 6NZ9 · PDBe 6NZ9 · UniProt P05042
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.