UniProt P05042
Fumarate hydratase class II (P05042)
Fumarate hydratase class II (UniProt P05042), EC 4.2.1.2: 27 experimental structures and 1 predicted model on GenesisL1, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05042
- Protein
- Fumarate hydratase class II
- EC
- 4.2.1.2
- Experimental structures
- 27
- Predicted models
- 1
- Pockets
- 28 · 3 records with a druggable one
Structures
28 records of P05042 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FUO | Fumarase C with bound citrate | x-ray diffraction | A, B | — | — |
| 1FUO | Fumarase C with bound citrate | x-ray diffraction | A, B | — | — |
| 1FUP | Fumarase with bound pyromellitic acid | x-ray diffraction | A, B | — | — |
| 1FUP | Fumarase with bound pyromellitic acid | x-ray diffraction | A, B | — | — |
| 1FUQ | Fumarase with bound 3-trimethylsilylsuccinic acid | x-ray diffraction | A, B | — | — |
| 1FUQ | Fumarase with bound 3-trimethylsilylsuccinic acid | x-ray diffraction | A, B | — | — |
| 1FUR | Fumarase mutant H188N with bound substrate L-malate at putative activator site | x-ray diffraction | A, B | — | — |
| 1FUR | Fumarase mutant H188N with bound substrate L-malate at putative activator site | x-ray diffraction | A, B | — | — |
| 1KQ7 | E315Q Mutant Form of Fumarase C from E.coli | x-ray diffraction | A, B | — | — |
| 1KQ7 | E315Q mutant form of fumarase C from E.COLI | x-ray diffraction | A, B | — | — |
| 1YFE | Crystal structure of apo fumarase C from Escherichia coli | x-ray diffraction | A | — | — |
| 1YFE | Crystal structure of apo fumarase C from escherichia COLI | x-ray diffraction | A | — | — |
| 2FUS | Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid… | x-ray diffraction | A, B | — | — |
| 2FUS | Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid… | x-ray diffraction | A, B | — | — |
| 6NZ9 | Crystal structure of E. coli fumarase C bound to citrate at 1.53 angstrom resolution | x-ray diffraction | A, B | — | 5 (best 0.53) |
| 6NZ9 | Crystal structure of E. COLI fumarase C bound to citrate at 1.53 ångström resolution | x-ray diffraction | A, B | — | — |
| 6NZA | Crystal structure of E. coli fumarase C K324A variant with closed SS Loop at 1.41 angstrom… | x-ray diffraction | A, B | — | 6 (best 0.70) |
| 6NZA | Crystal structure of E. COLI fumarase C K324A variant with closed ss loop at 1.41 ångström… | x-ray diffraction | A, B | — | — |
| 6NZB | Crystal structure of E. coli fumarase C S318A variant with closed SS Loop at 1.37 angstrom… | x-ray diffraction | A, B | — | — |
| 6NZB | Crystal structure of E. COLI fumarase C S318A variant with closed ss loop at 1.37 ångström… | x-ray diffraction | A, B | — | — |
| 6NZC | Crystal structure of E. coli fumarase C N326A variant with closed SS Loop at 1.40 angstrom… | x-ray diffraction | A, B | — | — |
| 6NZC | Crystal structure of E. COLI fumarase C N326A variant with closed ss loop at 1.40 ångström… | x-ray diffraction | A, B | — | — |
| 6OS7 | E. coli fumarase mutant - R126A | x-ray diffraction | A, B | — | 9 (best 0.71) |
| 6OS7 | E. COLI fumarase mutant - R126A | x-ray diffraction | A, B | — | — |
| 6P3C | E. coli fumarase mutant - T187A | x-ray diffraction | A, B | — | 5 (best 0.47) |
| 6P3C | E. COLI fumarase mutant - T187A | x-ray diffraction | A, B | — | — |
| 8SBS | Fumarate C - R126A in (3-(N-morpholino)propanesulfonic acid) at pH 7.5 | x-ray diffraction | A | — | 3 (best 0.43) |
| P05042 | AlphaFold monomer V2.0 prediction for fumarate hydratase class II (P05042) | predicted | A | — | — |
Experiment against prediction
- 6NZB chain B against the predicted model P05042: TM-score 0.98, RMSD 1.21 Å
- 6NZB chain B against the predicted model P05042: TM-score 0.98, RMSD 1.21 Å
- 6OS7 chain B against the predicted model P05042: TM-score 0.98, RMSD 1.27 Å
- 6OS7 chain B against the predicted model P05042: TM-score 0.97, RMSD 1.48 Å
- 6NZA chain B against the predicted model P05042: TM-score 0.97, RMSD 1.44 Å
- 6NZA chain B against the predicted model P05042: TM-score 0.97, RMSD 1.44 Å
- 6NZ9 chain B against the predicted model P05042: TM-score 0.97, RMSD 1.57 Å
- 6NZ9 chain B against the predicted model P05042: TM-score 0.97, RMSD 1.57 Å
- 6NZB chain A against the predicted model P05042: TM-score 0.97, RMSD 1.58 Å
- 6NZB chain A against the predicted model P05042: TM-score 0.97, RMSD 1.58 Å
Elsewhere
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